Relationship between expression of apoptosis-related proteins and the efficacy of postoperative chemotherapy in patients with T3 gastric cancer

Shunichi Tsujitani, Hiroaki Saito, Toshiro Wakatsuki, Masahide Ikeguchi, Ken Shirabe, Masaru Morita, Yoshihiro Kakeji, Tokujiro Yano, Yoshihiko Maehara

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Abstract

Purpose: We investigated the relationship between the p53-dependent apoptotic pathway and the survival of patients with gastric cancer, retrospectively, to elucidate new biomarkers of uracil/tegafur (UFT) chemotherapy. Methods: We examined the expression of p53, p21, Bax, and myeloid cell leukemia 1 (Mcl-1) proteins immunohistochemically in 105 patients who underwent curative gastrectomy for gastric cancer invading the serosa. Postoperative oral UFT was prescribed for 1 year. Kaplan-Meier survival curves were compared with the two-sided log-rank test. Results: Positive staining for p53, p21, Bax, and Mcl-1 proteins was found in 63.8, 52.4, 39.0, and 72.4% of the subjects, respectively. Survival time did not differ significantly between the patients with and those without p53, p21, and Bax expression. However, patients with Mcl-1(-) tumors survived longer than those with Mcl-1(+) tumors. Postoperative UFT treatment did not improve survival; however, adjuvant UFT significantly prolonged the survival of patients with p53(-), p21(-), Bax(+), or Mcl-1(+) tumors, but not of patients with p53(+), p21(+), Bax(-), or Mcl-1(-) tumors. Conclusions: The efficacy of adjuvant chemotherapy for gastric cancer may be affected by the status of apoptosis-related proteins such as p53, p21, Bax, and Mcl-1. However, because susceptibility to apoptosis did not explain the sensitivity of chemotherapeutic agents, further investigation of the mutual interaction between apoptosis-related proteins is required.

Original languageEnglish
Pages (from-to)225-232
Number of pages8
JournalSurgery today
Volume42
Issue number3
DOIs
Publication statusPublished - Feb 2012

All Science Journal Classification (ASJC) codes

  • Surgery

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    Tsujitani, S., Saito, H., Wakatsuki, T., Ikeguchi, M., Shirabe, K., Morita, M., Kakeji, Y., Yano, T., & Maehara, Y. (2012). Relationship between expression of apoptosis-related proteins and the efficacy of postoperative chemotherapy in patients with T3 gastric cancer. Surgery today, 42(3), 225-232. https://doi.org/10.1007/s00595-011-0062-z