Relationship between hyperemesis gravidarum and small-for-gestational-age in the Japanese population: The Japan Environment and Children's Study (JECS)

Japan Environment and Children's Study Group

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Small-for-gestational-age in infancy is a known risk factor not only for short-term prognosis but also for several long-term outcomes, such as neurological and metabolic disorders in adulthood. Previous research has shown that severe nausea and vomiting in early pregnancy (NVP) and hyperemesis gravidarum, which is an extreme form of NVP, represent risk factors for small-for-gestational-age birth. However, there is no clear consensus on this association. Thus, in the present study, we investigated the correlation between hyperemesis gravidarum and NVP on the one hand, and infant birth weight on the other, using data from the Japan Environment and Children's Study (JECS). Methods: The data utilized in the present study were obtained from the JECS, an ongoing cohort study that began in January 2011. Our sample size was 8635 parent-child pairs. The presence or absence of severe NVP, hyperemesis gravidarum, and potential confounding factors were noted. A multivariable regression analysis was used to estimate risks for small-for-gestational-age birth, and the results were expressed as risk ratios and 95 % confidence intervals. Results: The risk ratios of small-for-gestational-age birth (95 % confidence interval) for mothers with severe NVP and those with hyperemesis gravidarum were 0.86 (0.62-1.19) and 0.81 (0.39-1.66), respectively, which represents a non-significant result. Conclusions: In our analysis of JECS data, neither severe NVP nor hyperemesis gravidarum was associated with increased risk for small-for-gestational-age birth.

Original languageEnglish
Article number247
JournalBMC Pregnancy and Childbirth
Volume16
Issue number1
DOIs
Publication statusPublished - Aug 26 2016

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Hyperemesis Gravidarum
Nausea
Gestational Age
Vomiting
Japan
Pregnancy
Parturition
Population
Odds Ratio
Confidence Intervals
Nervous System Diseases
Birth Weight
Sample Size
Consensus
Cohort Studies
Regression Analysis
Mothers
Research

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

Relationship between hyperemesis gravidarum and small-for-gestational-age in the Japanese population : The Japan Environment and Children's Study (JECS). / Japan Environment and Children's Study Group.

In: BMC Pregnancy and Childbirth, Vol. 16, No. 1, 247, 26.08.2016.

Research output: Contribution to journalArticle

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abstract = "Background: Small-for-gestational-age in infancy is a known risk factor not only for short-term prognosis but also for several long-term outcomes, such as neurological and metabolic disorders in adulthood. Previous research has shown that severe nausea and vomiting in early pregnancy (NVP) and hyperemesis gravidarum, which is an extreme form of NVP, represent risk factors for small-for-gestational-age birth. However, there is no clear consensus on this association. Thus, in the present study, we investigated the correlation between hyperemesis gravidarum and NVP on the one hand, and infant birth weight on the other, using data from the Japan Environment and Children's Study (JECS). Methods: The data utilized in the present study were obtained from the JECS, an ongoing cohort study that began in January 2011. Our sample size was 8635 parent-child pairs. The presence or absence of severe NVP, hyperemesis gravidarum, and potential confounding factors were noted. A multivariable regression analysis was used to estimate risks for small-for-gestational-age birth, and the results were expressed as risk ratios and 95 {\%} confidence intervals. Results: The risk ratios of small-for-gestational-age birth (95 {\%} confidence interval) for mothers with severe NVP and those with hyperemesis gravidarum were 0.86 (0.62-1.19) and 0.81 (0.39-1.66), respectively, which represents a non-significant result. Conclusions: In our analysis of JECS data, neither severe NVP nor hyperemesis gravidarum was associated with increased risk for small-for-gestational-age birth.",
author = "{Japan Environment and Children's Study Group} and Seiichi Morokuma and Mototsugu Shimokawa and Kiyoko Kato and Masafumi Sanefuji and Eiji Shibata and Mayumi Tsuji and Ayako Senju and Toshihiro Kawamoto and Koichi Kusuhara and Hirohisa Saito and Reiko Kishi and Nobuo Yaegashi and Koichi Hashimoto and Chisato Mori and Fumiki Hirahara and Zentaro Yamagata and Hidekuni Inadera and Michihiro Kamijima and Ikuo Konishi and Hiroyasu Iso and Masayuki Shima and Toshihide Ogawa and Narufumi Suganuma and Takahiko Katoh",
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T2 - The Japan Environment and Children's Study (JECS)

AU - Japan Environment and Children's Study Group

AU - Morokuma, Seiichi

AU - Shimokawa, Mototsugu

AU - Kato, Kiyoko

AU - Sanefuji, Masafumi

AU - Shibata, Eiji

AU - Tsuji, Mayumi

AU - Senju, Ayako

AU - Kawamoto, Toshihiro

AU - Kusuhara, Koichi

AU - Saito, Hirohisa

AU - Kishi, Reiko

AU - Yaegashi, Nobuo

AU - Hashimoto, Koichi

AU - Mori, Chisato

AU - Hirahara, Fumiki

AU - Yamagata, Zentaro

AU - Inadera, Hidekuni

AU - Kamijima, Michihiro

AU - Konishi, Ikuo

AU - Iso, Hiroyasu

AU - Shima, Masayuki

AU - Ogawa, Toshihide

AU - Suganuma, Narufumi

AU - Katoh, Takahiko

PY - 2016/8/26

Y1 - 2016/8/26

N2 - Background: Small-for-gestational-age in infancy is a known risk factor not only for short-term prognosis but also for several long-term outcomes, such as neurological and metabolic disorders in adulthood. Previous research has shown that severe nausea and vomiting in early pregnancy (NVP) and hyperemesis gravidarum, which is an extreme form of NVP, represent risk factors for small-for-gestational-age birth. However, there is no clear consensus on this association. Thus, in the present study, we investigated the correlation between hyperemesis gravidarum and NVP on the one hand, and infant birth weight on the other, using data from the Japan Environment and Children's Study (JECS). Methods: The data utilized in the present study were obtained from the JECS, an ongoing cohort study that began in January 2011. Our sample size was 8635 parent-child pairs. The presence or absence of severe NVP, hyperemesis gravidarum, and potential confounding factors were noted. A multivariable regression analysis was used to estimate risks for small-for-gestational-age birth, and the results were expressed as risk ratios and 95 % confidence intervals. Results: The risk ratios of small-for-gestational-age birth (95 % confidence interval) for mothers with severe NVP and those with hyperemesis gravidarum were 0.86 (0.62-1.19) and 0.81 (0.39-1.66), respectively, which represents a non-significant result. Conclusions: In our analysis of JECS data, neither severe NVP nor hyperemesis gravidarum was associated with increased risk for small-for-gestational-age birth.

AB - Background: Small-for-gestational-age in infancy is a known risk factor not only for short-term prognosis but also for several long-term outcomes, such as neurological and metabolic disorders in adulthood. Previous research has shown that severe nausea and vomiting in early pregnancy (NVP) and hyperemesis gravidarum, which is an extreme form of NVP, represent risk factors for small-for-gestational-age birth. However, there is no clear consensus on this association. Thus, in the present study, we investigated the correlation between hyperemesis gravidarum and NVP on the one hand, and infant birth weight on the other, using data from the Japan Environment and Children's Study (JECS). Methods: The data utilized in the present study were obtained from the JECS, an ongoing cohort study that began in January 2011. Our sample size was 8635 parent-child pairs. The presence or absence of severe NVP, hyperemesis gravidarum, and potential confounding factors were noted. A multivariable regression analysis was used to estimate risks for small-for-gestational-age birth, and the results were expressed as risk ratios and 95 % confidence intervals. Results: The risk ratios of small-for-gestational-age birth (95 % confidence interval) for mothers with severe NVP and those with hyperemesis gravidarum were 0.86 (0.62-1.19) and 0.81 (0.39-1.66), respectively, which represents a non-significant result. Conclusions: In our analysis of JECS data, neither severe NVP nor hyperemesis gravidarum was associated with increased risk for small-for-gestational-age birth.

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