Relationship between impaired cardiac sympathetic activity and spatial dyssynchrony in patients with non-ischemic heart failure: Assessment by MIBG scintigraphy and tagged MRI

Masato Yonezawa, Michinobu Nagao, Koichiro Abe, Yoshio Matsuo, Shingo Baba, Takeshi Kamitani, Takuro Isoda, Yasuhiro Maruoka, Mikako Jinnouchi, Yuzo Yamasaki, Kohtaro Abe, Taiki Higo, Takashi Yoshiura, Hiroshi Honda

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6 Citations (Scopus)

Abstract

Background: Impairment of cardiac sympathetic activity has various detrimental effects on cardiac function. The purpose was to investigate the relationship between left ventricular (LV) dyssynchrony and cardiac sympathetic activity in non-ischemic heart failure (HF). Methods: Twenty-seven patients with non-ischemic HF were enrolled. Cardiac sympathetic activity was assessed by heart-to-mediastinum ratio (H/M ratio) on 123I- Metaiodobenzylguanidine scintigraphy. LV dyssynchrony was assessed by cross-correlation analysis of time curves of myocardial circumferential strains delivered from cine-tagging MR images. Temporal dyssynchrony was defined as contraction delay between septal and lateral segments >110 milliseconds. Spatial dyssynchrony was defined as the negative value of the maximum correlation for the two strain time curves. Results: H/M ratio was significantly lower for patients with spatial dyssynchrony compared to patients without (1.8 ± 0.3 vs 2.1 ± 0.3, P <.05). There was no difference between patients with and without temporal dyssynchrony (2.0 ± 0.2 vs 2.0 ± 0.3). The incidence of spatial dyssynchrony was significantly higher in patients with H/M ratio <2.0 than those whose ratios were ≥2.0 (75% vs 20%, P =.001). There was no difference in the incidence of temporal dyssynchrony between the two groups (17% vs 20%). Conclusion: Impairment of cardiac sympathetic activity was found to be associated with spatial dyssynchrony in patients with non-ischemic HF.

Original languageEnglish
Pages (from-to)600-608
Number of pages9
JournalJournal of Nuclear Cardiology
Volume20
Issue number4
DOIs
Publication statusPublished - Aug 1 2013

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3-Iodobenzylguanidine
Radionuclide Imaging
Heart Failure
Mediastinum
Incidence

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Relationship between impaired cardiac sympathetic activity and spatial dyssynchrony in patients with non-ischemic heart failure : Assessment by MIBG scintigraphy and tagged MRI. / Yonezawa, Masato; Nagao, Michinobu; Abe, Koichiro; Matsuo, Yoshio; Baba, Shingo; Kamitani, Takeshi; Isoda, Takuro; Maruoka, Yasuhiro; Jinnouchi, Mikako; Yamasaki, Yuzo; Abe, Kohtaro; Higo, Taiki; Yoshiura, Takashi; Honda, Hiroshi.

In: Journal of Nuclear Cardiology, Vol. 20, No. 4, 01.08.2013, p. 600-608.

Research output: Contribution to journalArticle

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abstract = "Background: Impairment of cardiac sympathetic activity has various detrimental effects on cardiac function. The purpose was to investigate the relationship between left ventricular (LV) dyssynchrony and cardiac sympathetic activity in non-ischemic heart failure (HF). Methods: Twenty-seven patients with non-ischemic HF were enrolled. Cardiac sympathetic activity was assessed by heart-to-mediastinum ratio (H/M ratio) on 123I- Metaiodobenzylguanidine scintigraphy. LV dyssynchrony was assessed by cross-correlation analysis of time curves of myocardial circumferential strains delivered from cine-tagging MR images. Temporal dyssynchrony was defined as contraction delay between septal and lateral segments >110 milliseconds. Spatial dyssynchrony was defined as the negative value of the maximum correlation for the two strain time curves. Results: H/M ratio was significantly lower for patients with spatial dyssynchrony compared to patients without (1.8 ± 0.3 vs 2.1 ± 0.3, P <.05). There was no difference between patients with and without temporal dyssynchrony (2.0 ± 0.2 vs 2.0 ± 0.3). The incidence of spatial dyssynchrony was significantly higher in patients with H/M ratio <2.0 than those whose ratios were ≥2.0 (75{\%} vs 20{\%}, P =.001). There was no difference in the incidence of temporal dyssynchrony between the two groups (17{\%} vs 20{\%}). Conclusion: Impairment of cardiac sympathetic activity was found to be associated with spatial dyssynchrony in patients with non-ischemic HF.",
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T1 - Relationship between impaired cardiac sympathetic activity and spatial dyssynchrony in patients with non-ischemic heart failure

T2 - Assessment by MIBG scintigraphy and tagged MRI

AU - Yonezawa, Masato

AU - Nagao, Michinobu

AU - Abe, Koichiro

AU - Matsuo, Yoshio

AU - Baba, Shingo

AU - Kamitani, Takeshi

AU - Isoda, Takuro

AU - Maruoka, Yasuhiro

AU - Jinnouchi, Mikako

AU - Yamasaki, Yuzo

AU - Abe, Kohtaro

AU - Higo, Taiki

AU - Yoshiura, Takashi

AU - Honda, Hiroshi

PY - 2013/8/1

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N2 - Background: Impairment of cardiac sympathetic activity has various detrimental effects on cardiac function. The purpose was to investigate the relationship between left ventricular (LV) dyssynchrony and cardiac sympathetic activity in non-ischemic heart failure (HF). Methods: Twenty-seven patients with non-ischemic HF were enrolled. Cardiac sympathetic activity was assessed by heart-to-mediastinum ratio (H/M ratio) on 123I- Metaiodobenzylguanidine scintigraphy. LV dyssynchrony was assessed by cross-correlation analysis of time curves of myocardial circumferential strains delivered from cine-tagging MR images. Temporal dyssynchrony was defined as contraction delay between septal and lateral segments >110 milliseconds. Spatial dyssynchrony was defined as the negative value of the maximum correlation for the two strain time curves. Results: H/M ratio was significantly lower for patients with spatial dyssynchrony compared to patients without (1.8 ± 0.3 vs 2.1 ± 0.3, P <.05). There was no difference between patients with and without temporal dyssynchrony (2.0 ± 0.2 vs 2.0 ± 0.3). The incidence of spatial dyssynchrony was significantly higher in patients with H/M ratio <2.0 than those whose ratios were ≥2.0 (75% vs 20%, P =.001). There was no difference in the incidence of temporal dyssynchrony between the two groups (17% vs 20%). Conclusion: Impairment of cardiac sympathetic activity was found to be associated with spatial dyssynchrony in patients with non-ischemic HF.

AB - Background: Impairment of cardiac sympathetic activity has various detrimental effects on cardiac function. The purpose was to investigate the relationship between left ventricular (LV) dyssynchrony and cardiac sympathetic activity in non-ischemic heart failure (HF). Methods: Twenty-seven patients with non-ischemic HF were enrolled. Cardiac sympathetic activity was assessed by heart-to-mediastinum ratio (H/M ratio) on 123I- Metaiodobenzylguanidine scintigraphy. LV dyssynchrony was assessed by cross-correlation analysis of time curves of myocardial circumferential strains delivered from cine-tagging MR images. Temporal dyssynchrony was defined as contraction delay between septal and lateral segments >110 milliseconds. Spatial dyssynchrony was defined as the negative value of the maximum correlation for the two strain time curves. Results: H/M ratio was significantly lower for patients with spatial dyssynchrony compared to patients without (1.8 ± 0.3 vs 2.1 ± 0.3, P <.05). There was no difference between patients with and without temporal dyssynchrony (2.0 ± 0.2 vs 2.0 ± 0.3). The incidence of spatial dyssynchrony was significantly higher in patients with H/M ratio <2.0 than those whose ratios were ≥2.0 (75% vs 20%, P =.001). There was no difference in the incidence of temporal dyssynchrony between the two groups (17% vs 20%). Conclusion: Impairment of cardiac sympathetic activity was found to be associated with spatial dyssynchrony in patients with non-ischemic HF.

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