TY - JOUR
T1 - Relationship between mitochondrial haplogroup and physiological responses to hypobaric hypoxia
AU - Motoi, Midori
AU - Nishimura, Takayuki
AU - Egashira, Yuka
AU - Kishida, Fumi
AU - Watanuki, Shigeki
N1 - Funding Information:
This study was supported in part by JSPS KAKENHI (23247044).
Publisher Copyright:
© 2016 Motoi et al.
PY - 2016/1/13
Y1 - 2016/1/13
N2 - We aimed to investigate the relationship between mtDNA polymorphism and physiological responses to hypobaric hypoxia. The study included 28 healthy male students, consisting of 18 students in haplogroup D and 10 in haplogroup M7+G. Measurement sensors were attached to the participants for approximately 30 min in an environment with a temperature of 28 °C. After resting for 15 min, the programmed operation of the hypobaric chamber decreased the atmospheric pressure by 11.9 Torr every minute to simulate an increase in altitude of 150 m until 9.7 Torr (equivalent to 2500 m) and then decreased 9.7 Torr every minute until 465 Torr (equivalent to 4000 m). At each altitude, the pressure was maintained for 15 min and various measurements were taken. Haplogroup D showed higher SpO 2 (p < 0.05) and significantly higher SpO 2 during the pressure recovery period when compared with haplogroup M7+G. The distal skin temperature was higher in haplogroup D when compared with M7+G. These results suggested that haplogroup D maintained SpO 2 at a higher level with higher peripheral blood flow during acute hypobaric exposure.
AB - We aimed to investigate the relationship between mtDNA polymorphism and physiological responses to hypobaric hypoxia. The study included 28 healthy male students, consisting of 18 students in haplogroup D and 10 in haplogroup M7+G. Measurement sensors were attached to the participants for approximately 30 min in an environment with a temperature of 28 °C. After resting for 15 min, the programmed operation of the hypobaric chamber decreased the atmospheric pressure by 11.9 Torr every minute to simulate an increase in altitude of 150 m until 9.7 Torr (equivalent to 2500 m) and then decreased 9.7 Torr every minute until 465 Torr (equivalent to 4000 m). At each altitude, the pressure was maintained for 15 min and various measurements were taken. Haplogroup D showed higher SpO 2 (p < 0.05) and significantly higher SpO 2 during the pressure recovery period when compared with haplogroup M7+G. The distal skin temperature was higher in haplogroup D when compared with M7+G. These results suggested that haplogroup D maintained SpO 2 at a higher level with higher peripheral blood flow during acute hypobaric exposure.
UR - http://www.scopus.com/inward/record.url?scp=85015700248&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85015700248&partnerID=8YFLogxK
U2 - 10.1186/s40101-016-0094-6
DO - 10.1186/s40101-016-0094-6
M3 - Article
C2 - 27130215
AN - SCOPUS:85015700248
VL - 35
JO - Journal of Physiological Anthropology
JF - Journal of Physiological Anthropology
SN - 1880-6791
IS - 1
M1 - 12
ER -