Relationship between normal serum creatinine concentration and periodontal disease in japanese middle-aged males

Yoshihiro Shimazaki, Mitoshi Kushiyama, Masatoshi Murakami, Yoshihisa Yamashita

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Periodontitis has been shown to be closely related to diabetes, which was recently found to be associated with lower serum creatinine. Conversely, several studies have suggested a positive relationship between periodontitis and abnormally high concentrations of serum creatinine associated with renal dysfunction, seemingly contradicting the above. This study evaluates periodontal status and serum levels of creatinine within the normal range to resolve this apparent contradiction. Methods:Acomprehensive health examination of 907 Japanese males, 49 to 59 years old, was performed from 2000 to 2002. A blood sample was collected from the antecubital vein after an overnight fast. The periodontal parameters were periodontal probing depth (PD) and clinical attachment loss (AL).We examined the association between serum creatinine concentration within the normal range and periodontal parameters. Results: Serum creatinine concentration within the normal range was inversely correlated with mean PD and mean AL. In multivariate linear regression analyses, every 0.1-mg/dL increment in serum creatinine concentration was associated with a 0.064-mm decrease in both mean PD and mean AL (P <0.05) after adjusting for confounding variables. Conclusion: This study finds a significant inverse association between normal serum creatinine concentration and periodontal disease.

Original languageEnglish
Pages (from-to)94-99
Number of pages6
JournalJournal of Periodontology
Volume84
Issue number1
DOIs
Publication statusPublished - Jan 1 2013

Fingerprint

Periodontal Diseases
Creatinine
Serum
Reference Values
Periodontitis
Confounding Factors (Epidemiology)
Veins
Linear Models
Regression Analysis
Kidney
Health

All Science Journal Classification (ASJC) codes

  • Periodontics

Cite this

Relationship between normal serum creatinine concentration and periodontal disease in japanese middle-aged males. / Shimazaki, Yoshihiro; Kushiyama, Mitoshi; Murakami, Masatoshi; Yamashita, Yoshihisa.

In: Journal of Periodontology, Vol. 84, No. 1, 01.01.2013, p. 94-99.

Research output: Contribution to journalArticle

Shimazaki, Yoshihiro ; Kushiyama, Mitoshi ; Murakami, Masatoshi ; Yamashita, Yoshihisa. / Relationship between normal serum creatinine concentration and periodontal disease in japanese middle-aged males. In: Journal of Periodontology. 2013 ; Vol. 84, No. 1. pp. 94-99.
@article{50e6e9057b9c43b88e026a9e71d94c99,
title = "Relationship between normal serum creatinine concentration and periodontal disease in japanese middle-aged males",
abstract = "Background: Periodontitis has been shown to be closely related to diabetes, which was recently found to be associated with lower serum creatinine. Conversely, several studies have suggested a positive relationship between periodontitis and abnormally high concentrations of serum creatinine associated with renal dysfunction, seemingly contradicting the above. This study evaluates periodontal status and serum levels of creatinine within the normal range to resolve this apparent contradiction. Methods:Acomprehensive health examination of 907 Japanese males, 49 to 59 years old, was performed from 2000 to 2002. A blood sample was collected from the antecubital vein after an overnight fast. The periodontal parameters were periodontal probing depth (PD) and clinical attachment loss (AL).We examined the association between serum creatinine concentration within the normal range and periodontal parameters. Results: Serum creatinine concentration within the normal range was inversely correlated with mean PD and mean AL. In multivariate linear regression analyses, every 0.1-mg/dL increment in serum creatinine concentration was associated with a 0.064-mm decrease in both mean PD and mean AL (P <0.05) after adjusting for confounding variables. Conclusion: This study finds a significant inverse association between normal serum creatinine concentration and periodontal disease.",
author = "Yoshihiro Shimazaki and Mitoshi Kushiyama and Masatoshi Murakami and Yoshihisa Yamashita",
year = "2013",
month = "1",
day = "1",
doi = "10.1902/jop.2012.110528",
language = "English",
volume = "84",
pages = "94--99",
journal = "Journal of Periodontology",
issn = "0022-3492",
publisher = "American Academy of Periodontology",
number = "1",

}

TY - JOUR

T1 - Relationship between normal serum creatinine concentration and periodontal disease in japanese middle-aged males

AU - Shimazaki, Yoshihiro

AU - Kushiyama, Mitoshi

AU - Murakami, Masatoshi

AU - Yamashita, Yoshihisa

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Background: Periodontitis has been shown to be closely related to diabetes, which was recently found to be associated with lower serum creatinine. Conversely, several studies have suggested a positive relationship between periodontitis and abnormally high concentrations of serum creatinine associated with renal dysfunction, seemingly contradicting the above. This study evaluates periodontal status and serum levels of creatinine within the normal range to resolve this apparent contradiction. Methods:Acomprehensive health examination of 907 Japanese males, 49 to 59 years old, was performed from 2000 to 2002. A blood sample was collected from the antecubital vein after an overnight fast. The periodontal parameters were periodontal probing depth (PD) and clinical attachment loss (AL).We examined the association between serum creatinine concentration within the normal range and periodontal parameters. Results: Serum creatinine concentration within the normal range was inversely correlated with mean PD and mean AL. In multivariate linear regression analyses, every 0.1-mg/dL increment in serum creatinine concentration was associated with a 0.064-mm decrease in both mean PD and mean AL (P <0.05) after adjusting for confounding variables. Conclusion: This study finds a significant inverse association between normal serum creatinine concentration and periodontal disease.

AB - Background: Periodontitis has been shown to be closely related to diabetes, which was recently found to be associated with lower serum creatinine. Conversely, several studies have suggested a positive relationship between periodontitis and abnormally high concentrations of serum creatinine associated with renal dysfunction, seemingly contradicting the above. This study evaluates periodontal status and serum levels of creatinine within the normal range to resolve this apparent contradiction. Methods:Acomprehensive health examination of 907 Japanese males, 49 to 59 years old, was performed from 2000 to 2002. A blood sample was collected from the antecubital vein after an overnight fast. The periodontal parameters were periodontal probing depth (PD) and clinical attachment loss (AL).We examined the association between serum creatinine concentration within the normal range and periodontal parameters. Results: Serum creatinine concentration within the normal range was inversely correlated with mean PD and mean AL. In multivariate linear regression analyses, every 0.1-mg/dL increment in serum creatinine concentration was associated with a 0.064-mm decrease in both mean PD and mean AL (P <0.05) after adjusting for confounding variables. Conclusion: This study finds a significant inverse association between normal serum creatinine concentration and periodontal disease.

UR - http://www.scopus.com/inward/record.url?scp=84872025673&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872025673&partnerID=8YFLogxK

U2 - 10.1902/jop.2012.110528

DO - 10.1902/jop.2012.110528

M3 - Article

C2 - 22390548

AN - SCOPUS:84872025673

VL - 84

SP - 94

EP - 99

JO - Journal of Periodontology

JF - Journal of Periodontology

SN - 0022-3492

IS - 1

ER -