Relationship between phagocytic activity of macrophages and delayed footpad reaction against syngeneic testicular cells

K. Nomoto, Yasunobu Yoshikai, S. Yoshida, S. Miake

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    The delayed footpad reaction against syngeneic testicular cells was studied in cyclophosphamide (CY)-pretreated mice whose mononuclear phagocyte system (MPS) was blocked with colloidal carbon or stimulated with Corynebacterium parvum (C. parvum). The delayed footpad reaction was augmented by MPS-blockade, whereas it was depressed by MPS-stimulation. It was observed that syngeneic testicular cells were phagocytized and degraded more effectively by C. parvum-stimulated macrophages in vitro and that the testicular antigen phagocytized by C. parvum-stimulated macrophages proved to become less immunogenic in cell transfer experiments.

    Original languageEnglish
    Pages (from-to)141-146
    Number of pages6
    JournalJournal of Clinical and Laboratory Immunology
    Volume7
    Issue number2
    Publication statusPublished - Jan 1 1982

    Fingerprint

    Propionibacterium acnes
    Mononuclear Phagocyte System
    Macrophages
    Cyclophosphamide
    Carbon
    Antigens

    All Science Journal Classification (ASJC) codes

    • Immunology

    Cite this

    Relationship between phagocytic activity of macrophages and delayed footpad reaction against syngeneic testicular cells. / Nomoto, K.; Yoshikai, Yasunobu; Yoshida, S.; Miake, S.

    In: Journal of Clinical and Laboratory Immunology, Vol. 7, No. 2, 01.01.1982, p. 141-146.

    Research output: Contribution to journalArticle

    @article{38af400352284963aea1c4dea5edb2f2,
    title = "Relationship between phagocytic activity of macrophages and delayed footpad reaction against syngeneic testicular cells",
    abstract = "The delayed footpad reaction against syngeneic testicular cells was studied in cyclophosphamide (CY)-pretreated mice whose mononuclear phagocyte system (MPS) was blocked with colloidal carbon or stimulated with Corynebacterium parvum (C. parvum). The delayed footpad reaction was augmented by MPS-blockade, whereas it was depressed by MPS-stimulation. It was observed that syngeneic testicular cells were phagocytized and degraded more effectively by C. parvum-stimulated macrophages in vitro and that the testicular antigen phagocytized by C. parvum-stimulated macrophages proved to become less immunogenic in cell transfer experiments.",
    author = "K. Nomoto and Yasunobu Yoshikai and S. Yoshida and S. Miake",
    year = "1982",
    month = "1",
    day = "1",
    language = "English",
    volume = "7",
    pages = "141--146",
    journal = "Journal of Clinical and Laboratory Immunology",
    issn = "0141-2760",
    publisher = "Teviot Scientific Publications Ltd.",
    number = "2",

    }

    TY - JOUR

    T1 - Relationship between phagocytic activity of macrophages and delayed footpad reaction against syngeneic testicular cells

    AU - Nomoto, K.

    AU - Yoshikai, Yasunobu

    AU - Yoshida, S.

    AU - Miake, S.

    PY - 1982/1/1

    Y1 - 1982/1/1

    N2 - The delayed footpad reaction against syngeneic testicular cells was studied in cyclophosphamide (CY)-pretreated mice whose mononuclear phagocyte system (MPS) was blocked with colloidal carbon or stimulated with Corynebacterium parvum (C. parvum). The delayed footpad reaction was augmented by MPS-blockade, whereas it was depressed by MPS-stimulation. It was observed that syngeneic testicular cells were phagocytized and degraded more effectively by C. parvum-stimulated macrophages in vitro and that the testicular antigen phagocytized by C. parvum-stimulated macrophages proved to become less immunogenic in cell transfer experiments.

    AB - The delayed footpad reaction against syngeneic testicular cells was studied in cyclophosphamide (CY)-pretreated mice whose mononuclear phagocyte system (MPS) was blocked with colloidal carbon or stimulated with Corynebacterium parvum (C. parvum). The delayed footpad reaction was augmented by MPS-blockade, whereas it was depressed by MPS-stimulation. It was observed that syngeneic testicular cells were phagocytized and degraded more effectively by C. parvum-stimulated macrophages in vitro and that the testicular antigen phagocytized by C. parvum-stimulated macrophages proved to become less immunogenic in cell transfer experiments.

    UR - http://www.scopus.com/inward/record.url?scp=0020086233&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0020086233&partnerID=8YFLogxK

    M3 - Article

    C2 - 7069784

    AN - SCOPUS:0020086233

    VL - 7

    SP - 141

    EP - 146

    JO - Journal of Clinical and Laboratory Immunology

    JF - Journal of Clinical and Laboratory Immunology

    SN - 0141-2760

    IS - 2

    ER -