Relationship between phagocytic activity of macrophages and delayed footpad reaction against syngeneic testicular cells

K. Nomoto, Yasunobu Yoshikai, S. Yoshida, S. Miake

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    The delayed footpad reaction against syngeneic testicular cells was studied in cyclophosphamide (CY)-pretreated mice whose mononuclear phagocyte system (MPS) was blocked with colloidal carbon or stimulated with Corynebacterium parvum (C. parvum). The delayed footpad reaction was augmented by MPS-blockade, whereas it was depressed by MPS-stimulation. It was observed that syngeneic testicular cells were phagocytized and degraded more effectively by C. parvum-stimulated macrophages in vitro and that the testicular antigen phagocytized by C. parvum-stimulated macrophages proved to become less immunogenic in cell transfer experiments.

    Original languageEnglish
    Pages (from-to)141-146
    Number of pages6
    JournalJournal of Clinical and Laboratory Immunology
    Issue number2
    Publication statusPublished - Jan 1 1982


    All Science Journal Classification (ASJC) codes

    • Immunology

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