Relationship between plasma glutathione levels and cardiovascular disease in a defined population

The Hisayama study

Haruki Shimizu, Yutaka Kiyohara, Isao Kato, Takanari Kitazono, Yumihiro Tanizaki, Michiaki Kubo, Hirofumi Ueno, Setsuro Ibayashi, Masatoshi Fujishima, Mitsuo Iida

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Background and Purpose-Glutathione (GSH) appears to have marked antioxidant activities and therefore may prevent cardiovascular disease (CVD). However, there are very few reports on this subject. In a community-based case-control study, we tested the hypothesis that low levels of plasma GSH are closely associated with CVD and its clinical types. Methods-The association between fasting plasma total GSH (tGSH) levels and CVD were assessed using conditional logistic regression analysis among 134 CVD cases and 435 age- and sex-matched healthy control subjects. Results-Mean tGSH concentrations were lower in all CVD cases than in the control subjects (3.06 versus 3.71 μmol/L; P=0.0001). Among the CVD types, both the cerebral infarction cases (2.98 versus 3.59 μmol/L; P=0.001) and cerebral hemorrhage cases (2.51 versus 3.43 μmol/L; P=0.0027) had significantly lower tGSH levels than the corresponding control groups had. The same tendency was observed for cases of subarachnoid hemorrhage (3.45 versus 3.83 μmol/L; P=0.36) and myocardial infarction (3.65 versus 3.77 μmol/L; P=0.69), but these differences were not statistically significant. After adjustment for other confounding factors, the risk of CVD was significantly lower in the third (adjusted odds ratio, 041; 95% CI, 0.21 to 0.77) and the fourth quartiles (adjusted odds ratio, 0.25; 95% CI, 0.12 to 0.51) than in the first. This association was most prominent in patients with lacunar infarction or cerebral hemorrhage. Conclusions-These findings suggest that reduced plasma tGSH levels are a risk factor for CVD, especially for cerebral small vessel disease.

Original languageEnglish
Pages (from-to)2072-2077
Number of pages6
JournalStroke
Volume35
Issue number9
DOIs
Publication statusPublished - Sep 1 2004

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Glutathione
Cardiovascular Diseases
Population
Cerebral Hemorrhage
Cerebral Small Vessel Diseases
Odds Ratio
Lacunar Stroke
Cerebral Infarction
Subarachnoid Hemorrhage
Case-Control Studies
Fasting
Healthy Volunteers
Antioxidants
Logistic Models
Myocardial Infarction
Regression Analysis
Control Groups

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

Cite this

Relationship between plasma glutathione levels and cardiovascular disease in a defined population : The Hisayama study. / Shimizu, Haruki; Kiyohara, Yutaka; Kato, Isao; Kitazono, Takanari; Tanizaki, Yumihiro; Kubo, Michiaki; Ueno, Hirofumi; Ibayashi, Setsuro; Fujishima, Masatoshi; Iida, Mitsuo.

In: Stroke, Vol. 35, No. 9, 01.09.2004, p. 2072-2077.

Research output: Contribution to journalArticle

Shimizu, H, Kiyohara, Y, Kato, I, Kitazono, T, Tanizaki, Y, Kubo, M, Ueno, H, Ibayashi, S, Fujishima, M & Iida, M 2004, 'Relationship between plasma glutathione levels and cardiovascular disease in a defined population: The Hisayama study', Stroke, vol. 35, no. 9, pp. 2072-2077. https://doi.org/10.1161/01.STR.0000138022.86509.2d
Shimizu, Haruki ; Kiyohara, Yutaka ; Kato, Isao ; Kitazono, Takanari ; Tanizaki, Yumihiro ; Kubo, Michiaki ; Ueno, Hirofumi ; Ibayashi, Setsuro ; Fujishima, Masatoshi ; Iida, Mitsuo. / Relationship between plasma glutathione levels and cardiovascular disease in a defined population : The Hisayama study. In: Stroke. 2004 ; Vol. 35, No. 9. pp. 2072-2077.
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