Relationship between pulmonary fat embolism and core body temperature in rats with a severe fatty liver

Hiromasa Inoue, Noriaki Ikeda, Keiko Kudo, Akiko Tsuji, Masayuki Nata

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We previously demonstrated that pulmonary fat embolism was induced by elevation of the core body temperature, in rats with a fatty liver. The aim of the present examination was to investigate the core body temperature at which pulmonary fat embolism developed capillaries through exposure to a high temperature, in rats with a fatty liver. Following heat stress, pulmonary fat embolism was observed to a slight degree at a core body temperature of 41 and 42 °C, whereas the severity of pulmonary fat embolism was greatly increased and was classified as severe at a core body temperature of 43 °C. Moreover, the concentrations of aspartate aminotransferase and alanine aminotransferase within plasma were significantly increased at a core body temperature of 43 °C. These results clearly indicate that the development of pulmonary fat embolism could be related to hyperthermia at above 42 °C following heat stress, and that fat emboli may be derived from the fatty liver itself. It is thus likely that pulmonary fat embolism can be considered as one form of evidence of hyperthermia in an individual with a fatty liver.

Original languageEnglish
Pages (from-to)210-213
Number of pages4
JournalLegal Medicine
Volume8
Issue number4
DOIs
Publication statusPublished - Jul 1 2006

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Fat Embolism
Fatty Liver
Body Temperature
Pulmonary Embolism
Fever
Hot Temperature
Aspartate Aminotransferases
Embolism
Alanine Transaminase
Fats
Temperature

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Issues, ethics and legal aspects

Cite this

Relationship between pulmonary fat embolism and core body temperature in rats with a severe fatty liver. / Inoue, Hiromasa; Ikeda, Noriaki; Kudo, Keiko; Tsuji, Akiko; Nata, Masayuki.

In: Legal Medicine, Vol. 8, No. 4, 01.07.2006, p. 210-213.

Research output: Contribution to journalArticle

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