Relationship Between Real-Time Monitoring of the Graft Motility and Mucosal Histology in Swine Intestinal Transplantation

Toshiharu Matsuura, Tomoaki Taguchi, M. Hayashida, K. Ogita, N. Takada, Y. Nishimoto, S. Taguchi, T. Uesugi, T. Kondo, R. Hirose, S. Suita

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We studied the correlation between the motility and the mucosal histology of the small bowel seeking to detect rejection in an early stage by real-time monitoring using a swine model. Intestinal transplantation (ITx) was performed orthotopically using FK506 immunosuppression. The distal about 20 cm segment of the allograft was exteriorized as a Thiry-Vella stoma for biopsies. Strain gauge (SG) force transducers were attached to the graft for real-time monitoring of graft motility. Pigs without ITx were used as controls (group 1). Rejection was classified into four groups by histologic findings: nonrejection (group 2), mild rejection (group 3), moderate rejection (group 4), and severe rejection (group 5). Migrating motor complex (MMC) phase III was analyzed for the following parameters: duration, amplitude, interval, motility index, velocity, and frequency of propagation. In group 2, all parameters were almost the same as those for group 1. In contrast, groups 4 and 5 showed most parameters significantly lower than those in group 1. In group 3, the contractility of the MMC was not significantly altered, but the frequency of the propagation was decreased significantly. In conclusion, graft motility detected by a real-time SG method correlated with the grade of mucosal histology. This method is useful to detect rejection at an early stage by examining the frequency of MMC propagation.

Original languageEnglish
Pages (from-to)1851-1852
Number of pages2
JournalTransplantation Proceedings
Volume38
Issue number6
DOIs
Publication statusPublished - Jul 1 2006

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Migrating Myoelectric Complexes
Histology
Swine
Transplantation
Transplants
Tacrolimus
Transducers
Immunosuppression
Allografts
Biopsy
Control Groups

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

Relationship Between Real-Time Monitoring of the Graft Motility and Mucosal Histology in Swine Intestinal Transplantation. / Matsuura, Toshiharu; Taguchi, Tomoaki; Hayashida, M.; Ogita, K.; Takada, N.; Nishimoto, Y.; Taguchi, S.; Uesugi, T.; Kondo, T.; Hirose, R.; Suita, S.

In: Transplantation Proceedings, Vol. 38, No. 6, 01.07.2006, p. 1851-1852.

Research output: Contribution to journalArticle

Matsuura, T, Taguchi, T, Hayashida, M, Ogita, K, Takada, N, Nishimoto, Y, Taguchi, S, Uesugi, T, Kondo, T, Hirose, R & Suita, S 2006, 'Relationship Between Real-Time Monitoring of the Graft Motility and Mucosal Histology in Swine Intestinal Transplantation', Transplantation Proceedings, vol. 38, no. 6, pp. 1851-1852. https://doi.org/10.1016/j.transproceed.2006.06.086
Matsuura, Toshiharu ; Taguchi, Tomoaki ; Hayashida, M. ; Ogita, K. ; Takada, N. ; Nishimoto, Y. ; Taguchi, S. ; Uesugi, T. ; Kondo, T. ; Hirose, R. ; Suita, S. / Relationship Between Real-Time Monitoring of the Graft Motility and Mucosal Histology in Swine Intestinal Transplantation. In: Transplantation Proceedings. 2006 ; Vol. 38, No. 6. pp. 1851-1852.
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