Relationship between rTMS effects and MEP features before rTMS

Kazuhisa Nojima, Keiji Iramina

Research output: Contribution to journalArticle

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Abstract

Repetitive transcranial magnetic stimulation (rTMS) is a promising method for use in the clinical field, as it can induce modulation of cortical excitability. Generally, rTMS inhibits the motor cortex when delivered at less than 1 Hz. However, it has been indicated that a facilitative effect is induced by 1 Hz rTMS, depending on the stimulation parameters and the individual. Therefore, the aim of this study was to investigate the features of the subject that could affect the 1 Hz rTMS effect when rTMS stimulus conditions change. First, motor evoked potentials (MEP) were measured under rTMS conditions with a variety of stimulus intensities and numbers of pulses. The MEP features before rTMS and the MEP modulation by the rTMS were then analyzed. Furthermore, correlations between the MEP features and the rTMS effect were investigated. It was found that the MEP amplitude and MEP onset before rTMS can influence the rTMS effect. Furthermore, negative correlations were found between these MEP features and the rTMS effect. MEPs with a small amplitude and early latency were little influenced by the inhibitive effect of 1 Hz rTMS, while MEPs with a large amplitude and late latency were readily affected by the inhibitive effect of 1 Hz rTMS. In this study, we focused on the MEP features before rTMS and identified the features of the subject that could influence the rTMS effect when the rTMS stimulus condition was changed.

Original languageEnglish
Pages (from-to)110-115
Number of pages6
JournalNeuroscience Letters
Volume664
DOIs
Publication statusPublished - Jan 18 2018

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Motor Evoked Potentials
Transcranial Magnetic Stimulation
Motor Cortex

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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Relationship between rTMS effects and MEP features before rTMS. / Nojima, Kazuhisa; Iramina, Keiji.

In: Neuroscience Letters, Vol. 664, 18.01.2018, p. 110-115.

Research output: Contribution to journalArticle

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