Relationship Between Susceptibility to Apoptosis and Fas Expression in Peripheral Blood T Cells from Uremic Patients: A Possible Mechanism for Lymphopenia in Chronic Renal Failure

Y. Matsumoto, T. Shinzato, I. Amano, I. Takai, Y. Kimura, H. Morita, M. Miwa, K. Nakane, Y. Yoshikai, K. Maeda

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    Abstract

    Chronic renal failure (CRF) is often complicated by lymphopenia, which may be partly responsible for immune deficiency. We hypothesized that lymphopenia in CRF might result from apoptosis of T cells in vivo. To elucidate the involvement of Fas antigen which mediates apoptosis, we analyzed Fas expression on peripheral blood T cells in uremic non-dialyzed (non-HD) patients and hemodialysis (HD) patients. T cells from both uremic groups expressed Fas with higher intensity than control T cells. When two uremic groups were compared, Fas intensity on T cells was significantly higher in non-HD patients than in patients on HD. Moreover, uremic T cells were shown to undergo accelerated apoptosis when cultured in vitro, in correlation with Fas expression. Our results suggest that T cells in CRF may undergo apoptosis by the Fas system and that hemodialysis treatment has beneficial effects in the light of the inhibition of T cell apoptosis.

    Original languageEnglish
    Pages (from-to)98-105
    Number of pages8
    JournalBiochemical and Biophysical Research Communications
    Volume215
    Issue number1
    DOIs
    Publication statusPublished - Oct 4 1995

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    All Science Journal Classification (ASJC) codes

    • Biophysics
    • Biochemistry
    • Molecular Biology
    • Cell Biology

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