Relationship between the curative effects of carbamazepine administration and the neurovascular compression volume of the trigeminal nerve measured using magnetic resonance cisternography

Tatsurou Tanaka, Eiji Sakamoto, Shunji Shiiba, Masafumi Oda, Shinji Kito, Nao Wakasugi-Sato, Shinobu Matsumoto-Takeda, Yoshiki Imamura, Osamu Nakanishi, Yasuhiro Morimoto

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

OBJECTIVES: To elucidate the relationship between the extent of pain and neurovascular compression (NVC) volume, measured by magnetic resonance (MR) cisternography, in patients with trigeminal neuralgia. In addition, we aimed to evaluate the relationship between NVC volume and the efficacy of carbamazepine administration in patients with trigeminal neuralgia. METHODS: MR cisternography was performed on 214 patients with clinical signs and symptoms that suggested trigeminal neuralgia retrospectively. The extent of their pain was evaluated using visual analog scales. Next, only carbamazepine was administered as the initial treatment. For the patients with NVC detectable on MR cisternography, the relationship between the extent or nature of the pain and the neurovascular volume was analyzed. In addition, the correlation between the efficacy of carbamazepine treatment and the NVC volume was evaluated retrospectively. RESULTS: Of the 214 patients evaluated, 144 were deemed to have NVC. In these 144 patients, a significant difference was found between the NVC volume and the curative effects of 100mg/d carbamazepine. However, no significant correlation was found between the extents of pain by visual analog score or between the daily dosage of carbamazepine and the NVC volume measured by MR cisternography. CONCLUSIONS: Three-dimensional MR cisternography is very useful for detecting the site of NVC in patients with trigeminal neuralgia. NVC measured by this technique may indicate the prognosis after initial treatment. The present results suggest that the evaluation of NVC volume by MR cisternography would be useful in choosing the initial treatment for patients with trigeminal neuralgia.

Original languageEnglish
Pages (from-to)752-759
Number of pages8
JournalClinical Journal of Pain
Volume25
Issue number9
DOIs
Publication statusPublished - Jan 1 2009
Externally publishedYes

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Trigeminal Nerve
Carbamazepine
Magnetic Resonance Spectroscopy
Trigeminal Neuralgia
Pain
Visual Analog Scale
Signs and Symptoms
Therapeutics

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

Relationship between the curative effects of carbamazepine administration and the neurovascular compression volume of the trigeminal nerve measured using magnetic resonance cisternography. / Tanaka, Tatsurou; Sakamoto, Eiji; Shiiba, Shunji; Oda, Masafumi; Kito, Shinji; Wakasugi-Sato, Nao; Matsumoto-Takeda, Shinobu; Imamura, Yoshiki; Nakanishi, Osamu; Morimoto, Yasuhiro.

In: Clinical Journal of Pain, Vol. 25, No. 9, 01.01.2009, p. 752-759.

Research output: Contribution to journalArticle

Tanaka, Tatsurou ; Sakamoto, Eiji ; Shiiba, Shunji ; Oda, Masafumi ; Kito, Shinji ; Wakasugi-Sato, Nao ; Matsumoto-Takeda, Shinobu ; Imamura, Yoshiki ; Nakanishi, Osamu ; Morimoto, Yasuhiro. / Relationship between the curative effects of carbamazepine administration and the neurovascular compression volume of the trigeminal nerve measured using magnetic resonance cisternography. In: Clinical Journal of Pain. 2009 ; Vol. 25, No. 9. pp. 752-759.
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AU - Sakamoto, Eiji

AU - Shiiba, Shunji

AU - Oda, Masafumi

AU - Kito, Shinji

AU - Wakasugi-Sato, Nao

AU - Matsumoto-Takeda, Shinobu

AU - Imamura, Yoshiki

AU - Nakanishi, Osamu

AU - Morimoto, Yasuhiro

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AB - OBJECTIVES: To elucidate the relationship between the extent of pain and neurovascular compression (NVC) volume, measured by magnetic resonance (MR) cisternography, in patients with trigeminal neuralgia. In addition, we aimed to evaluate the relationship between NVC volume and the efficacy of carbamazepine administration in patients with trigeminal neuralgia. METHODS: MR cisternography was performed on 214 patients with clinical signs and symptoms that suggested trigeminal neuralgia retrospectively. The extent of their pain was evaluated using visual analog scales. Next, only carbamazepine was administered as the initial treatment. For the patients with NVC detectable on MR cisternography, the relationship between the extent or nature of the pain and the neurovascular volume was analyzed. In addition, the correlation between the efficacy of carbamazepine treatment and the NVC volume was evaluated retrospectively. RESULTS: Of the 214 patients evaluated, 144 were deemed to have NVC. In these 144 patients, a significant difference was found between the NVC volume and the curative effects of 100mg/d carbamazepine. However, no significant correlation was found between the extents of pain by visual analog score or between the daily dosage of carbamazepine and the NVC volume measured by MR cisternography. CONCLUSIONS: Three-dimensional MR cisternography is very useful for detecting the site of NVC in patients with trigeminal neuralgia. NVC measured by this technique may indicate the prognosis after initial treatment. The present results suggest that the evaluation of NVC volume by MR cisternography would be useful in choosing the initial treatment for patients with trigeminal neuralgia.

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