Relationship of genotype rather than race to hepatitis B virus pathogenicity: A study of Japanese and Solomon islanders

Norihiro Furusyo, Norihiko Kubo, Hisashi Nakashima, Kenichiro Kashiwagi, Jun Hayashi

Research output: Contribution to journalArticle

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Abstract

The aim of this study was to determine the predominant hepatitis B virus (HBV) genotype in the Solomon Islands and determine if there is any racial correlation between genotype and hepatitis B e antigen (HBeAg) production in Japanese and Melanesian individuals. A total of 403 serum samples from 206 Melanesian HBV carriers in the Solomon Islands and 197 Japanese carriers from Fukuoka (n = 106) and Okinawa (n = 91) living in Japan in 2001 were tested. The HBV genotypes of 206 Melanesian subjects were 114 with genotype C (55.3%) and 92 with genotype D (44.7%). The HBV genotypes of 197 Japanese subjects were 74 with genotype B (37.6%) and 123 with genotype C (62.4%). The total HBeAg prevalence of subjects in Fukuoka (36.8%) was significantly higher than that of subjects in Okinawa (14.3%) (P < 0.0001) and subjects in the Solomon Islands (35.0%; P = 0.0014, by the Mantel-Haenszel test). The genotype C prevalences were significantly different, ranging from 24.2% in Okinawa, to 54.4% in the Solomon Islands, to 95.3% in Fukuoka (all P < 0.0001, by chi-square test). The prevalence of HBeAg positivity was significantly higher in Melanesian genotype C subjects (42.0%) than Melanesian genotype D subjects (26.6%) (P = 0.0310). Similarly, the prevalence of HBeAg positivity was significantly higher in Japanese genotype C subjects (36.6%) than Japanese genotype B subjects (9.5%) (P < 0.0001). These findings indicate that that HBV was of genotypes C and D in the Solomon Islands, and that the pathogenesis of HBV-infected patients is related to HBV genotype rather than race.

Original languageEnglish
Pages (from-to)571-575
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume70
Issue number5
Publication statusPublished - May 1 2004

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Hepatitis B virus
Virulence
Genotype
Melanesia
Hepatitis B e Antigens
Chi-Square Distribution
Japan

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Relationship of genotype rather than race to hepatitis B virus pathogenicity : A study of Japanese and Solomon islanders. / Furusyo, Norihiro; Kubo, Norihiko; Nakashima, Hisashi; Kashiwagi, Kenichiro; Hayashi, Jun.

In: American Journal of Tropical Medicine and Hygiene, Vol. 70, No. 5, 01.05.2004, p. 571-575.

Research output: Contribution to journalArticle

Furusyo, Norihiro ; Kubo, Norihiko ; Nakashima, Hisashi ; Kashiwagi, Kenichiro ; Hayashi, Jun. / Relationship of genotype rather than race to hepatitis B virus pathogenicity : A study of Japanese and Solomon islanders. In: American Journal of Tropical Medicine and Hygiene. 2004 ; Vol. 70, No. 5. pp. 571-575.
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abstract = "The aim of this study was to determine the predominant hepatitis B virus (HBV) genotype in the Solomon Islands and determine if there is any racial correlation between genotype and hepatitis B e antigen (HBeAg) production in Japanese and Melanesian individuals. A total of 403 serum samples from 206 Melanesian HBV carriers in the Solomon Islands and 197 Japanese carriers from Fukuoka (n = 106) and Okinawa (n = 91) living in Japan in 2001 were tested. The HBV genotypes of 206 Melanesian subjects were 114 with genotype C (55.3{\%}) and 92 with genotype D (44.7{\%}). The HBV genotypes of 197 Japanese subjects were 74 with genotype B (37.6{\%}) and 123 with genotype C (62.4{\%}). The total HBeAg prevalence of subjects in Fukuoka (36.8{\%}) was significantly higher than that of subjects in Okinawa (14.3{\%}) (P < 0.0001) and subjects in the Solomon Islands (35.0{\%}; P = 0.0014, by the Mantel-Haenszel test). The genotype C prevalences were significantly different, ranging from 24.2{\%} in Okinawa, to 54.4{\%} in the Solomon Islands, to 95.3{\%} in Fukuoka (all P < 0.0001, by chi-square test). The prevalence of HBeAg positivity was significantly higher in Melanesian genotype C subjects (42.0{\%}) than Melanesian genotype D subjects (26.6{\%}) (P = 0.0310). Similarly, the prevalence of HBeAg positivity was significantly higher in Japanese genotype C subjects (36.6{\%}) than Japanese genotype B subjects (9.5{\%}) (P < 0.0001). These findings indicate that that HBV was of genotypes C and D in the Solomon Islands, and that the pathogenesis of HBV-infected patients is related to HBV genotype rather than race.",
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