Relationship of high-density lipoprotein cholesterol and red blood cell filterability: Cross-sectional study of healthy subjects

Jun Ichi Ejima, Tetsuo Ijichi, Yasushi Ohnishi, Toru Maruyama, Yoshikazu Kaji, Shozo Kanaya, Takehiko Fujino, Nobuhiro Uyesaka, Takeshi Ohmura

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The deformability of red blood cells (RBCs) is an important rheologic factor in the maintenance of normal blood flow in the microcirculation. Contrary to the well-known relationship between hyperlipidemia and atherosclerosis, the relationship between RBC rheology and the serum lipid profile has remained controversial and obscure. Moreover, the correlation of high-density lipoprotein (HDL)-cholesterol and RBC deformability has not been fully understood. In the present cross-sectional study of 139 apparently healthy subjects, we investigated whole-cell deformability (filterability) of RBCs in relation to the lipid profile, using a nickel mesh filter with 3.2- μm pores. RBC filterability was independent of gender, age and serum levels of low-density lipoprotein (LDL)-cholesterol. The filterability was significantly proportional to the HDL-cholesterol values (r = 0.382, p < 0.01), whereas it was inversely proportional to the triglyceride levels (r = -0.259, p < 0.01). These findings may provide new insight into the role of HDL-cholesterol not only in preventing atherosclerotic progression but also in improving RBC filterability.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalClinical Hemorheology and Microcirculation
Volume22
Issue number1
Publication statusPublished - Mar 21 2000

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HDL Cholesterol
Healthy Volunteers
Cross-Sectional Studies
Erythrocytes
Lipids
Rheology
Microcirculation
Hyperlipidemias
Nickel
Serum
LDL Cholesterol
Atherosclerosis
Triglycerides
Maintenance

All Science Journal Classification (ASJC) codes

  • Physiology
  • Hematology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Relationship of high-density lipoprotein cholesterol and red blood cell filterability : Cross-sectional study of healthy subjects. / Ejima, Jun Ichi; Ijichi, Tetsuo; Ohnishi, Yasushi; Maruyama, Toru; Kaji, Yoshikazu; Kanaya, Shozo; Fujino, Takehiko; Uyesaka, Nobuhiro; Ohmura, Takeshi.

In: Clinical Hemorheology and Microcirculation, Vol. 22, No. 1, 21.03.2000, p. 1-7.

Research output: Contribution to journalArticle

Ejima, JI, Ijichi, T, Ohnishi, Y, Maruyama, T, Kaji, Y, Kanaya, S, Fujino, T, Uyesaka, N & Ohmura, T 2000, 'Relationship of high-density lipoprotein cholesterol and red blood cell filterability: Cross-sectional study of healthy subjects', Clinical Hemorheology and Microcirculation, vol. 22, no. 1, pp. 1-7.
Ejima, Jun Ichi ; Ijichi, Tetsuo ; Ohnishi, Yasushi ; Maruyama, Toru ; Kaji, Yoshikazu ; Kanaya, Shozo ; Fujino, Takehiko ; Uyesaka, Nobuhiro ; Ohmura, Takeshi. / Relationship of high-density lipoprotein cholesterol and red blood cell filterability : Cross-sectional study of healthy subjects. In: Clinical Hemorheology and Microcirculation. 2000 ; Vol. 22, No. 1. pp. 1-7.
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