Relationship of periodontal infection to serum antibody levels to periodontopathic bacteria and inflammatory markers in periodontitis patients with coronary heart disease

K. Yamazaki, T. Honda, H. Domon, T. Okui, K. Kajita, R. Amanuma, C. Kudoh, S. Takashiba, S. Kokeguchi, F. Nishimura, M. Kodama, Y. Aizawa, H. Oda

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Several reports have demonstrated a possible association of periodontal infections with coronary heart disease (CHD) by elevated antibody titre to periodontopathic bacteria in CHD patients compared with non-diseased controls. Although each periodontopathic bacterium may vary in virulence for periodontitis and atherosclerosis, antibody response to multiple bacteria in CHD patients has not been understood fully. Therefore, serum levels of antibody to 12 periodontopathic bacteria together with other atherosclerotic risk markers were compared among 51 patients with CHD, 55 patients with moderate to severe chronic periodontitis and 37 healthy individuals. The antibody response was the most prevalent for Porphyromonas gingivalis, a major causative organism, in CHD as well as periodontitis patients. However, antibody positivity was different between CHD and periodontitis if the response was analysed for two different strains of P. gingivalis, namely FDC381 and Su63. While periodontitis patients were positive for both P. gingivalis FDC381 and Su63, a high frequency of antibody positivity for P. gingivalis Su63 but not for FDC381 was observed in CHD patients. The results indicate that the presence of particular periodontopathic bacteria with high virulence may affect atherogenesis. Identifying the virulence factors of P. gingivalis Su63 may gain insight into the new therapeutic modality for infection-induced deterioration of atherosclerosis.

Original languageEnglish
Pages (from-to)445-452
Number of pages8
JournalClinical and Experimental Immunology
Volume149
Issue number3
DOIs
Publication statusPublished - Sep 1 2007
Externally publishedYes

Fingerprint

Periodontitis
Porphyromonas gingivalis
Coronary Disease
Bacteria
Antibodies
Infection
Serum
Atherosclerosis
Antibody Formation
Virulence
Chronic Periodontitis
Virulence Factors

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Relationship of periodontal infection to serum antibody levels to periodontopathic bacteria and inflammatory markers in periodontitis patients with coronary heart disease. / Yamazaki, K.; Honda, T.; Domon, H.; Okui, T.; Kajita, K.; Amanuma, R.; Kudoh, C.; Takashiba, S.; Kokeguchi, S.; Nishimura, F.; Kodama, M.; Aizawa, Y.; Oda, H.

In: Clinical and Experimental Immunology, Vol. 149, No. 3, 01.09.2007, p. 445-452.

Research output: Contribution to journalArticle

Yamazaki, K. ; Honda, T. ; Domon, H. ; Okui, T. ; Kajita, K. ; Amanuma, R. ; Kudoh, C. ; Takashiba, S. ; Kokeguchi, S. ; Nishimura, F. ; Kodama, M. ; Aizawa, Y. ; Oda, H. / Relationship of periodontal infection to serum antibody levels to periodontopathic bacteria and inflammatory markers in periodontitis patients with coronary heart disease. In: Clinical and Experimental Immunology. 2007 ; Vol. 149, No. 3. pp. 445-452.
@article{856fca016e384bc68b35104ac88c1905,
title = "Relationship of periodontal infection to serum antibody levels to periodontopathic bacteria and inflammatory markers in periodontitis patients with coronary heart disease",
abstract = "Several reports have demonstrated a possible association of periodontal infections with coronary heart disease (CHD) by elevated antibody titre to periodontopathic bacteria in CHD patients compared with non-diseased controls. Although each periodontopathic bacterium may vary in virulence for periodontitis and atherosclerosis, antibody response to multiple bacteria in CHD patients has not been understood fully. Therefore, serum levels of antibody to 12 periodontopathic bacteria together with other atherosclerotic risk markers were compared among 51 patients with CHD, 55 patients with moderate to severe chronic periodontitis and 37 healthy individuals. The antibody response was the most prevalent for Porphyromonas gingivalis, a major causative organism, in CHD as well as periodontitis patients. However, antibody positivity was different between CHD and periodontitis if the response was analysed for two different strains of P. gingivalis, namely FDC381 and Su63. While periodontitis patients were positive for both P. gingivalis FDC381 and Su63, a high frequency of antibody positivity for P. gingivalis Su63 but not for FDC381 was observed in CHD patients. The results indicate that the presence of particular periodontopathic bacteria with high virulence may affect atherogenesis. Identifying the virulence factors of P. gingivalis Su63 may gain insight into the new therapeutic modality for infection-induced deterioration of atherosclerosis.",
author = "K. Yamazaki and T. Honda and H. Domon and T. Okui and K. Kajita and R. Amanuma and C. Kudoh and S. Takashiba and S. Kokeguchi and F. Nishimura and M. Kodama and Y. Aizawa and H. Oda",
year = "2007",
month = "9",
day = "1",
doi = "10.1111/j.1365-2249.2007.03450.x",
language = "English",
volume = "149",
pages = "445--452",
journal = "Clinical and Experimental Immunology",
issn = "0009-9104",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Relationship of periodontal infection to serum antibody levels to periodontopathic bacteria and inflammatory markers in periodontitis patients with coronary heart disease

AU - Yamazaki, K.

AU - Honda, T.

AU - Domon, H.

AU - Okui, T.

AU - Kajita, K.

AU - Amanuma, R.

AU - Kudoh, C.

AU - Takashiba, S.

AU - Kokeguchi, S.

AU - Nishimura, F.

AU - Kodama, M.

AU - Aizawa, Y.

AU - Oda, H.

PY - 2007/9/1

Y1 - 2007/9/1

N2 - Several reports have demonstrated a possible association of periodontal infections with coronary heart disease (CHD) by elevated antibody titre to periodontopathic bacteria in CHD patients compared with non-diseased controls. Although each periodontopathic bacterium may vary in virulence for periodontitis and atherosclerosis, antibody response to multiple bacteria in CHD patients has not been understood fully. Therefore, serum levels of antibody to 12 periodontopathic bacteria together with other atherosclerotic risk markers were compared among 51 patients with CHD, 55 patients with moderate to severe chronic periodontitis and 37 healthy individuals. The antibody response was the most prevalent for Porphyromonas gingivalis, a major causative organism, in CHD as well as periodontitis patients. However, antibody positivity was different between CHD and periodontitis if the response was analysed for two different strains of P. gingivalis, namely FDC381 and Su63. While periodontitis patients were positive for both P. gingivalis FDC381 and Su63, a high frequency of antibody positivity for P. gingivalis Su63 but not for FDC381 was observed in CHD patients. The results indicate that the presence of particular periodontopathic bacteria with high virulence may affect atherogenesis. Identifying the virulence factors of P. gingivalis Su63 may gain insight into the new therapeutic modality for infection-induced deterioration of atherosclerosis.

AB - Several reports have demonstrated a possible association of periodontal infections with coronary heart disease (CHD) by elevated antibody titre to periodontopathic bacteria in CHD patients compared with non-diseased controls. Although each periodontopathic bacterium may vary in virulence for periodontitis and atherosclerosis, antibody response to multiple bacteria in CHD patients has not been understood fully. Therefore, serum levels of antibody to 12 periodontopathic bacteria together with other atherosclerotic risk markers were compared among 51 patients with CHD, 55 patients with moderate to severe chronic periodontitis and 37 healthy individuals. The antibody response was the most prevalent for Porphyromonas gingivalis, a major causative organism, in CHD as well as periodontitis patients. However, antibody positivity was different between CHD and periodontitis if the response was analysed for two different strains of P. gingivalis, namely FDC381 and Su63. While periodontitis patients were positive for both P. gingivalis FDC381 and Su63, a high frequency of antibody positivity for P. gingivalis Su63 but not for FDC381 was observed in CHD patients. The results indicate that the presence of particular periodontopathic bacteria with high virulence may affect atherogenesis. Identifying the virulence factors of P. gingivalis Su63 may gain insight into the new therapeutic modality for infection-induced deterioration of atherosclerosis.

UR - http://www.scopus.com/inward/record.url?scp=34547899523&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547899523&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2249.2007.03450.x

DO - 10.1111/j.1365-2249.2007.03450.x

M3 - Article

C2 - 17645769

AN - SCOPUS:34547899523

VL - 149

SP - 445

EP - 452

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

SN - 0009-9104

IS - 3

ER -