TY - JOUR
T1 - Relationship of serum fatty acid composition and desaturase activity to C-reactive protein in Japanese men and women
AU - Poudel-Tandukar, Kalpana
AU - Sato, Masao
AU - Ejima, Yuko
AU - Nanri, Akiko
AU - Matsushita, Yumi
AU - Imaizumi, Katsumi
AU - Mizoue, Tetsuya
N1 - Funding Information:
The authors would like to thank the study subjects for their cooperation and participation. The authors also thank Tamami Hatano, Yasumi Kimura, and Akihiro Tanaka (Kyushu University); Mio Ozawa (Fukuoka Women's University); and Akiko Hayashi and Kie Nagao (National Center for Global Health and Medicine, Japan) for their help in data collection. This study was supported by a Grant-in-Aid for Scientific Research (C) ( 18590601 ) and (B) ( 21390213 ) from the Japan Society for the Promotion of Science .
PY - 2012/2
Y1 - 2012/2
N2 - Background: Although fatty acid composition in serum and desaturase activity, which alters serum fatty acid composition, has been associated with C-reactive protein (CRP) concentration in Western populations, no study has been carried out in non-Western populations. We examined the association of serum fatty acids and estimated desaturase activity with CRP concentrations in Japanese men and women. Methods: Subjects were 489 Japanese municipal employees aged 21-67 years who participated in a survey at the time of a periodic health check-up. Serum high-sensitivity CRP concentrations were measured using the latex agglutination nephelometry method. Fatty acid composition was measured in serum cholesteryl esters and desaturase activities by fatty acid product-to-precursor ratios. Relationships were assessed using multiple regression. Results: Serum CRP concentration was positively associated with palmitic acid (P for trend = 0.002) and inversely with alpha-linolenic acid (P for trend = 0.01) in men, and positively with dihomo-gamma-linolenic acid (P for trend in men or women = 0.01) and inversely with delta-5-desaturase (20:4n-6/20:3n-6) (P for trend in men and women = 0.05 and 0.002, respectively) in men and women. Conclusions: Low-grade inflammation may be associated with a serum fatty acid pattern of high palmitic acid or low alpha-linolenic acid in men, and of high dihomo-gamma-linolenic acid or low delta-5-desaturase in both sexes.
AB - Background: Although fatty acid composition in serum and desaturase activity, which alters serum fatty acid composition, has been associated with C-reactive protein (CRP) concentration in Western populations, no study has been carried out in non-Western populations. We examined the association of serum fatty acids and estimated desaturase activity with CRP concentrations in Japanese men and women. Methods: Subjects were 489 Japanese municipal employees aged 21-67 years who participated in a survey at the time of a periodic health check-up. Serum high-sensitivity CRP concentrations were measured using the latex agglutination nephelometry method. Fatty acid composition was measured in serum cholesteryl esters and desaturase activities by fatty acid product-to-precursor ratios. Relationships were assessed using multiple regression. Results: Serum CRP concentration was positively associated with palmitic acid (P for trend = 0.002) and inversely with alpha-linolenic acid (P for trend = 0.01) in men, and positively with dihomo-gamma-linolenic acid (P for trend in men or women = 0.01) and inversely with delta-5-desaturase (20:4n-6/20:3n-6) (P for trend in men and women = 0.05 and 0.002, respectively) in men and women. Conclusions: Low-grade inflammation may be associated with a serum fatty acid pattern of high palmitic acid or low alpha-linolenic acid in men, and of high dihomo-gamma-linolenic acid or low delta-5-desaturase in both sexes.
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U2 - 10.1016/j.atherosclerosis.2011.11.012
DO - 10.1016/j.atherosclerosis.2011.11.012
M3 - Article
C2 - 22153152
AN - SCOPUS:84855961134
SN - 0021-9150
VL - 220
SP - 520
EP - 524
JO - Atherosclerosis
JF - Atherosclerosis
IS - 2
ER -