Relationships between Half-Lives of Dioxins and SNPs in AhR among Yusho Patients

Shinya Matsumoto, Manabu Akahane, Yoshiyuki Kanagawa, Jumboku Kajiwara, Kiyomi Tsukimori, Norio Wake, Chikage Mitoma, Hiroshi Uchi, Masutaka Furue, Tomoaki Imamura

Research output: Contribution to journalArticlepeer-review

Abstract

Half-lives of blood levels of 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) are varied in Yusho patients. The objective was to evaluate a relationship between half-lives of PeCDF levels and types of SNP rs10249788 of aryl hydrocarbon receptor (AHR) gene in 93 Yusho patients. Based on physical symptoms, age, sex, body mass index and other factors, we set up suitable calculation formulas to fit the actual PeCDF levels thorough rates of change in PeCDF. We found that patients with C/T SNP had longer half lives than patients with C/C and T/T SNPs. Patients with T/T SNP are known to express higher amount of AHR mRNAs. However, detailed analysis could not be carried out in T/T group due to a limited number of patients (n = 11). Further research is warranted to determine the cause of the longer half-lives in C/T patients.

Original languageEnglish
Pages (from-to)139-143
Number of pages5
JournalFukuoka igaku zasshi = Hukuoka acta medica
Volume106
Issue number5
Publication statusPublished - May 1 2015

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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