Relationships between hematopoietic stem cells and lymphocyte progenitors

Yoshihiro Baba, Rosana Pelayo, Paul W. Kincade

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


Remarkable advances have been made in characterizing highly purified hematopoietic stem cells and their lymphoid progeny. The majority of the cytokines and cell interaction molecules that comprise their environment are probably known, as are most cell cycle regulatory proteins, signaling molecules and transcription factors that mediate the lineage fate decisions and control population dynamics. However, it is becoming obvious that traditional differentiation diagrams are not adequate for depicting early changes and give overly rigid impressions about how cells of the immune system arise.

Original languageEnglish
Pages (from-to)645-649
Number of pages5
JournalTrends in Immunology
Issue number12
Publication statusPublished - Dec 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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