TY - JOUR
T1 - Relationships between hematopoietic stem cells and lymphocyte progenitors
AU - Baba, Yoshihiro
AU - Pelayo, Rosana
AU - Kincade, Paul W.
N1 - Funding Information:
This work was supported by grants AI-20069, AI-058162 from the National Institutes of Health and P20-RR15577 from the COBRE Program of the National Center for Research Resources.
PY - 2004/12
Y1 - 2004/12
N2 - Remarkable advances have been made in characterizing highly purified hematopoietic stem cells and their lymphoid progeny. The majority of the cytokines and cell interaction molecules that comprise their environment are probably known, as are most cell cycle regulatory proteins, signaling molecules and transcription factors that mediate the lineage fate decisions and control population dynamics. However, it is becoming obvious that traditional differentiation diagrams are not adequate for depicting early changes and give overly rigid impressions about how cells of the immune system arise.
AB - Remarkable advances have been made in characterizing highly purified hematopoietic stem cells and their lymphoid progeny. The majority of the cytokines and cell interaction molecules that comprise their environment are probably known, as are most cell cycle regulatory proteins, signaling molecules and transcription factors that mediate the lineage fate decisions and control population dynamics. However, it is becoming obvious that traditional differentiation diagrams are not adequate for depicting early changes and give overly rigid impressions about how cells of the immune system arise.
UR - http://www.scopus.com/inward/record.url?scp=7644242791&partnerID=8YFLogxK
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U2 - 10.1016/j.it.2004.09.010
DO - 10.1016/j.it.2004.09.010
M3 - Article
C2 - 15530833
AN - SCOPUS:7644242791
SN - 1471-4906
VL - 25
SP - 645
EP - 649
JO - Trends in Immunology
JF - Trends in Immunology
IS - 12
ER -