Relationships between perceived workload, stress and oxidative DNA damage

Masahiro Irie, Shinya Asami, Shoji Nagata, Masakazu Miyata, Hiroshi Kasai

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Objectives: The present study was performed to investigate the relationship between work-related factors, including psychological stress, and the formation of a type of oxidative DNA damage, 8-hydroxydeoxyguanosine (8-OH-dG), in order to examine their possible risk factor for occupational carcinogenesis. Methods: A total of 54 healthy workers (27 male and 27 female, aged 41.2 ± 12.5 years) in a company were investigated for 8-OH-dG levels in the peripheral blood leukocytes at the time of a questionnaire survey regarding several factors, such as working hours, workload, fatigue, sleep, psychological stress and the prospect of alleviating it. Subjects were limited to non-smoking and non-drinking workers to exclude the influence of cigarette smoking and alcohol drinking, which have been reported to have associations with the formation of 8-OH-dG. Results: The levels of 8-OH-dG in female subjects were significantly related to the perceived workload (F = 5.56, P = 0.010), the perceived psychological stress (F = 6.15, P = 0.007), and the impossibility of alleviating stress (F = 3.82, P = 0.048). No associations were observed in male subjects. Conclusions: Psychological stress and perceived overwork appear to be related to the pathogenesis of cancer via the formation of 8-OH-dG, particularly in female workers.

Original languageEnglish
Pages (from-to)153-157
Number of pages5
JournalInternational Archives of Occupational and Environmental Health
Volume74
Issue number2
DOIs
Publication statusPublished - Apr 2 2001
Externally publishedYes

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Workload
DNA Damage
Oxidative Stress
Psychological Stress
Alcohol Drinking
Fatigue
8-oxo-7-hydrodeoxyguanosine
Sleep
Carcinogenesis
Leukocytes
Smoking
hydroxide ion
Neoplasms

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Relationships between perceived workload, stress and oxidative DNA damage. / Irie, Masahiro; Asami, Shinya; Nagata, Shoji; Miyata, Masakazu; Kasai, Hiroshi.

In: International Archives of Occupational and Environmental Health, Vol. 74, No. 2, 02.04.2001, p. 153-157.

Research output: Contribution to journalArticle

Irie, Masahiro ; Asami, Shinya ; Nagata, Shoji ; Miyata, Masakazu ; Kasai, Hiroshi. / Relationships between perceived workload, stress and oxidative DNA damage. In: International Archives of Occupational and Environmental Health. 2001 ; Vol. 74, No. 2. pp. 153-157.
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