Relationships between serum antioxidant and oxidant statuses and visual function in retinitis pigmentosa

Masataka Ishizu, Yusuke Murakami, Kohta Fujiwara, Jun Funatsu, Shotaro Shimokawa, Shunji Nakatake, Takashi Tachibana, Toshio Hisatomi, Yoshito Koyanagi, Masato Akiyama, Yukihide Momozawa, Tatsuro Ishibashi, Koh Hei Sonoda, Yasuhiro Ikeda

Research output: Contribution to journalArticle

Abstract

PURPOSE. To investigate the serum changes of antioxidant/oxidant markers and the relationship between these factors and visual function in patients with retinitis pigmentosa (RP). METHODS. Fifty-two RP patients <40 years old and 25 controls were included. Serum samples were analyzed for superoxide dismutase 3 (SOD3) activity, glutathione peroxidase (GPx), potential antioxidant (PAO), and hexanoyl-lysine (HEL). The relationships between these markers and visual parameters, including best-corrected visual acuity (BCVA), mean deviation (MD), and average retinal sensitivity of 4 or 12 central points on static perimetry tests (Humphrey Field Analyzer, the central 10–2 program) were examined in the RP patients. RESULTS. Although there was no significant difference in the serum SOD3 activity between RP patients and controls, serum SOD3 activity in the severe degeneration group with macular involvement (16.3 6 11.3 U/mL) was significantly lower compared with those in the mild degeneration group (those with midperipheral scotomas; 28.5 6 16.6 U/mL, P ¼ 0.0459). SOD3 was significantly related to visual acuity (r ¼ -0.3701, P ¼ 0.0069) and the average retinal sensitivity of four central points (r ¼ 0.3463, P ¼ 0.0137) in RP patients. The linear trends of these two parameters across SOD3 levels were also significant (P ¼ 0.0264 and 0.0172, respectively). There was no consistent correlation between other serum antioxidant/ oxidant markers and visual parameters. CONCLUSIONS. Lower serum SOD3 activity was associated with the severe retinal degeneration in RP patients. Our results suggest that serum SOD3 activity may be related to disease severity in RP.

Original languageEnglish
Pages (from-to)4462-4468
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume60
Issue number13
DOIs
Publication statusPublished - Jan 1 2019

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Retinitis Pigmentosa
Oxidants
Superoxide Dismutase
Antioxidants
Serum
Visual Acuity
Scotoma
Retinal Degeneration
Visual Field Tests
Glutathione Peroxidase
Lysine

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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Relationships between serum antioxidant and oxidant statuses and visual function in retinitis pigmentosa. / Ishizu, Masataka; Murakami, Yusuke; Fujiwara, Kohta; Funatsu, Jun; Shimokawa, Shotaro; Nakatake, Shunji; Tachibana, Takashi; Hisatomi, Toshio; Koyanagi, Yoshito; Akiyama, Masato; Momozawa, Yukihide; Ishibashi, Tatsuro; Sonoda, Koh Hei; Ikeda, Yasuhiro.

In: Investigative Ophthalmology and Visual Science, Vol. 60, No. 13, 01.01.2019, p. 4462-4468.

Research output: Contribution to journalArticle

Ishizu, M, Murakami, Y, Fujiwara, K, Funatsu, J, Shimokawa, S, Nakatake, S, Tachibana, T, Hisatomi, T, Koyanagi, Y, Akiyama, M, Momozawa, Y, Ishibashi, T, Sonoda, KH & Ikeda, Y 2019, 'Relationships between serum antioxidant and oxidant statuses and visual function in retinitis pigmentosa', Investigative Ophthalmology and Visual Science, vol. 60, no. 13, pp. 4462-4468. https://doi.org/10.1167/iovs.19-26927
Ishizu, Masataka ; Murakami, Yusuke ; Fujiwara, Kohta ; Funatsu, Jun ; Shimokawa, Shotaro ; Nakatake, Shunji ; Tachibana, Takashi ; Hisatomi, Toshio ; Koyanagi, Yoshito ; Akiyama, Masato ; Momozawa, Yukihide ; Ishibashi, Tatsuro ; Sonoda, Koh Hei ; Ikeda, Yasuhiro. / Relationships between serum antioxidant and oxidant statuses and visual function in retinitis pigmentosa. In: Investigative Ophthalmology and Visual Science. 2019 ; Vol. 60, No. 13. pp. 4462-4468.
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abstract = "PURPOSE. To investigate the serum changes of antioxidant/oxidant markers and the relationship between these factors and visual function in patients with retinitis pigmentosa (RP). METHODS. Fifty-two RP patients <40 years old and 25 controls were included. Serum samples were analyzed for superoxide dismutase 3 (SOD3) activity, glutathione peroxidase (GPx), potential antioxidant (PAO), and hexanoyl-lysine (HEL). The relationships between these markers and visual parameters, including best-corrected visual acuity (BCVA), mean deviation (MD), and average retinal sensitivity of 4 or 12 central points on static perimetry tests (Humphrey Field Analyzer, the central 10–2 program) were examined in the RP patients. RESULTS. Although there was no significant difference in the serum SOD3 activity between RP patients and controls, serum SOD3 activity in the severe degeneration group with macular involvement (16.3 6 11.3 U/mL) was significantly lower compared with those in the mild degeneration group (those with midperipheral scotomas; 28.5 6 16.6 U/mL, P ¼ 0.0459). SOD3 was significantly related to visual acuity (r ¼ -0.3701, P ¼ 0.0069) and the average retinal sensitivity of four central points (r ¼ 0.3463, P ¼ 0.0137) in RP patients. The linear trends of these two parameters across SOD3 levels were also significant (P ¼ 0.0264 and 0.0172, respectively). There was no consistent correlation between other serum antioxidant/ oxidant markers and visual parameters. CONCLUSIONS. Lower serum SOD3 activity was associated with the severe retinal degeneration in RP patients. Our results suggest that serum SOD3 activity may be related to disease severity in RP.",
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T1 - Relationships between serum antioxidant and oxidant statuses and visual function in retinitis pigmentosa

AU - Ishizu, Masataka

AU - Murakami, Yusuke

AU - Fujiwara, Kohta

AU - Funatsu, Jun

AU - Shimokawa, Shotaro

AU - Nakatake, Shunji

AU - Tachibana, Takashi

AU - Hisatomi, Toshio

AU - Koyanagi, Yoshito

AU - Akiyama, Masato

AU - Momozawa, Yukihide

AU - Ishibashi, Tatsuro

AU - Sonoda, Koh Hei

AU - Ikeda, Yasuhiro

PY - 2019/1/1

Y1 - 2019/1/1

N2 - PURPOSE. To investigate the serum changes of antioxidant/oxidant markers and the relationship between these factors and visual function in patients with retinitis pigmentosa (RP). METHODS. Fifty-two RP patients <40 years old and 25 controls were included. Serum samples were analyzed for superoxide dismutase 3 (SOD3) activity, glutathione peroxidase (GPx), potential antioxidant (PAO), and hexanoyl-lysine (HEL). The relationships between these markers and visual parameters, including best-corrected visual acuity (BCVA), mean deviation (MD), and average retinal sensitivity of 4 or 12 central points on static perimetry tests (Humphrey Field Analyzer, the central 10–2 program) were examined in the RP patients. RESULTS. Although there was no significant difference in the serum SOD3 activity between RP patients and controls, serum SOD3 activity in the severe degeneration group with macular involvement (16.3 6 11.3 U/mL) was significantly lower compared with those in the mild degeneration group (those with midperipheral scotomas; 28.5 6 16.6 U/mL, P ¼ 0.0459). SOD3 was significantly related to visual acuity (r ¼ -0.3701, P ¼ 0.0069) and the average retinal sensitivity of four central points (r ¼ 0.3463, P ¼ 0.0137) in RP patients. The linear trends of these two parameters across SOD3 levels were also significant (P ¼ 0.0264 and 0.0172, respectively). There was no consistent correlation between other serum antioxidant/ oxidant markers and visual parameters. CONCLUSIONS. Lower serum SOD3 activity was associated with the severe retinal degeneration in RP patients. Our results suggest that serum SOD3 activity may be related to disease severity in RP.

AB - PURPOSE. To investigate the serum changes of antioxidant/oxidant markers and the relationship between these factors and visual function in patients with retinitis pigmentosa (RP). METHODS. Fifty-two RP patients <40 years old and 25 controls were included. Serum samples were analyzed for superoxide dismutase 3 (SOD3) activity, glutathione peroxidase (GPx), potential antioxidant (PAO), and hexanoyl-lysine (HEL). The relationships between these markers and visual parameters, including best-corrected visual acuity (BCVA), mean deviation (MD), and average retinal sensitivity of 4 or 12 central points on static perimetry tests (Humphrey Field Analyzer, the central 10–2 program) were examined in the RP patients. RESULTS. Although there was no significant difference in the serum SOD3 activity between RP patients and controls, serum SOD3 activity in the severe degeneration group with macular involvement (16.3 6 11.3 U/mL) was significantly lower compared with those in the mild degeneration group (those with midperipheral scotomas; 28.5 6 16.6 U/mL, P ¼ 0.0459). SOD3 was significantly related to visual acuity (r ¼ -0.3701, P ¼ 0.0069) and the average retinal sensitivity of four central points (r ¼ 0.3463, P ¼ 0.0137) in RP patients. The linear trends of these two parameters across SOD3 levels were also significant (P ¼ 0.0264 and 0.0172, respectively). There was no consistent correlation between other serum antioxidant/ oxidant markers and visual parameters. CONCLUSIONS. Lower serum SOD3 activity was associated with the severe retinal degeneration in RP patients. Our results suggest that serum SOD3 activity may be related to disease severity in RP.

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