Relationships of the systolic blood pressure response during exercise with insulin resistance, obesity, and endurance fitness in men with type 2 diabetes mellitus

Shuzo Kumagai, Y. Kai, H. Hanada, K. Uezono, H. Sasaki

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18 Citations (Scopus)

Abstract

The purpose of the present study was to investigate the relationships among the resting systolic (SBP) and diastolic blood pressure (DBP) or SBP response during exercise with insulin resistance evaluated by a homeostasis model (HOMA-IR), abdominal fat accumulation (visceral fat area [VFA], subcutaneous fat area [SFA]) by computed tomography (CT), and an estimation of the maximal oxygen uptake (V̇o2max) in 63 Japanese middle-aged male patients with type 2 diabetes mellitus (type 2 DM). Body mass index (BMI) and waist-to-hip ratio (WHR) in type 2 DM subjects were significantly higher than in age-matched healthy male control subjects (n = 135) with normal glucose tolerance. Resting SBP (127.7 ± 16.2 mm Hg v 119.4 ± 13.0 mm Hg) and DBP (82.2 ± 11.9 mm Hg v 76.8 ± 9.4 mm Hg) levels, and the percentage of hypertension (20.6% v 1.5%) in type 2 DM subjects were significantly higher than in the control subjects (P < .05). According to a multiple regression analysis for resting blood pressure in type 2 DM, VFA was found to be an independent predictor of SBP, while V̇o2max and HOMA-IR were independent predictors of DBP. In the controls, however, HOMA-IR was not found to be a significantly independent predictor for either resting SBP or resting DBP. Measurement of the SBP response during graded exercise using a ramp test was performed by an electrical braked cycle ergometer in 54 patients with type 2 DM only. The SBP was measured at 15-second intervals during exercise. The exercise intensity at the double product breaking point (DPBP), which strongly correlated with the exercise intensity at the lactate threshold, was used an as index for the SBP response to standardized exercise intensity. The SBP corresponding to exercise intensity at DPBP (SBP@DPBP) was evaluated as an index of the SBP response to standardized exercise intensity. The change in SBP (ΔSBP = SBP@DPBP - resting SBP) was significantly and positively associated with log area under the curve for glucose (log AUCPG) during a 75-g oral glucose tolerance test (OGTT). In addition, ΔSBP significantly and negatively correlated with the log area under the curve for insulin (log AUCIRI) and log AUCIRI/log AUCPG. Based on these results, insulin resistance was suggested to be independently associated with the resting DBP and SBP response to standardized exercise intensity in type 2 DM patients.

Original languageEnglish
Pages (from-to)1247-1252
Number of pages6
JournalMetabolism: Clinical and Experimental
Volume51
Issue number10
DOIs
Publication statusPublished - Oct 1 2002

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Type 2 Diabetes Mellitus
Insulin Resistance
Obesity
Exercise
Blood Pressure
Intra-Abdominal Fat
Area Under Curve
Glucose
Abdominal Fat
Architectural Accessibility
Waist-Hip Ratio
Subcutaneous Fat
Glucose Tolerance Test
Lactic Acid
Body Mass Index
Homeostasis
Tomography
Regression Analysis
Insulin
Oxygen

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Relationships of the systolic blood pressure response during exercise with insulin resistance, obesity, and endurance fitness in men with type 2 diabetes mellitus. / Kumagai, Shuzo; Kai, Y.; Hanada, H.; Uezono, K.; Sasaki, H.

In: Metabolism: Clinical and Experimental, Vol. 51, No. 10, 01.10.2002, p. 1247-1252.

Research output: Contribution to journalArticle

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