Reliability of HOMA-IR for evaluation of insulin resistance during perioperative period

Hiroko Flfjino, Shoko Itoda, Saori Sako, Kazuki Matsuo, Eiji Sakamoto, Takeshi Yokoyama

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background : Hyperglycemia due to increase in insulin resistance (IR) is often observed after surgery in spite of normal insulin secretion. To evaluate the degree of IR, the golden standard method is the normoglycemic hyperinsulinemic clamp technique (glucose clamp GC). The GC using the artificial pancreas, STG®-22 (Nikkiso, Tokyo, Japan), was established as a more reliable method, since it was evaluated during steady-state period under constant insulin infusion. Homeostasis model assessment insulin resistance (HOMA-IR), however, is frequently employed in daily practice because of its convenience. We1 therefore, investigated the reliability of HOMA-IR in comparison with the glucose clamp using the STG® Methods : Eight healthy patients undergoing maxillofacial surgery were employed in this study after obtaining written informed consent. Their insulin resistance was evaluated by HOMA-IR and the GC using the STG®before and after surgery. Results : HOMA-IR increased from 0.81 ±0.48 to 1.17±0.50, although there were no significant differences between before and after surgery. On the other hand, M-value by GC significantly decreased after surgery from 8.82±2.49mg • kg-1 • min-1 to 3.84±0.79 mg • kg-1 • min-1 (P=0.0003). In addition, no significant correlation was found between the values of HOMA-IR and the M-value by GC. Conclusions : HOMA-IR may not be reliable to evaluate IR for perioperative period.

Original languageEnglish
Pages (from-to)140-146
Number of pages7
JournalJapanese Journal of Anesthesiology
Volume62
Issue number2
Publication statusPublished - Feb 2013

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Perioperative Period
Insulin Resistance
Homeostasis
Glucose Clamp Technique
Artificial Pancreas
Insulin
Tokyo
Oral Surgery
Informed Consent
Hyperglycemia
Japan

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

Reliability of HOMA-IR for evaluation of insulin resistance during perioperative period. / Flfjino, Hiroko; Itoda, Shoko; Sako, Saori; Matsuo, Kazuki; Sakamoto, Eiji; Yokoyama, Takeshi.

In: Japanese Journal of Anesthesiology, Vol. 62, No. 2, 02.2013, p. 140-146.

Research output: Contribution to journalArticle

Flfjino, Hiroko ; Itoda, Shoko ; Sako, Saori ; Matsuo, Kazuki ; Sakamoto, Eiji ; Yokoyama, Takeshi. / Reliability of HOMA-IR for evaluation of insulin resistance during perioperative period. In: Japanese Journal of Anesthesiology. 2013 ; Vol. 62, No. 2. pp. 140-146.
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abstract = "Background : Hyperglycemia due to increase in insulin resistance (IR) is often observed after surgery in spite of normal insulin secretion. To evaluate the degree of IR, the golden standard method is the normoglycemic hyperinsulinemic clamp technique (glucose clamp GC). The GC using the artificial pancreas, STG{\circledR}-22 (Nikkiso, Tokyo, Japan), was established as a more reliable method, since it was evaluated during steady-state period under constant insulin infusion. Homeostasis model assessment insulin resistance (HOMA-IR), however, is frequently employed in daily practice because of its convenience. We1 therefore, investigated the reliability of HOMA-IR in comparison with the glucose clamp using the STG{\circledR} Methods : Eight healthy patients undergoing maxillofacial surgery were employed in this study after obtaining written informed consent. Their insulin resistance was evaluated by HOMA-IR and the GC using the STG{\circledR}before and after surgery. Results : HOMA-IR increased from 0.81 ±0.48 to 1.17±0.50, although there were no significant differences between before and after surgery. On the other hand, M-value by GC significantly decreased after surgery from 8.82±2.49mg • kg-1 • min-1 to 3.84±0.79 mg • kg-1 • min-1 (P=0.0003). In addition, no significant correlation was found between the values of HOMA-IR and the M-value by GC. Conclusions : HOMA-IR may not be reliable to evaluate IR for perioperative period.",
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