Reliability of mean transit time obtained using perfusion-weighted MR imaging; comparison with positron emission tomography

Futoshi Mihara, Yasuo Kuwabara, Atsuo Tanaka, Takashi Yoshiura, Masayuki Sasaki, Tsuyoshi Yoshida, Kouji Masuda, Toshio Matsushima

Research output: Contribution to journalArticle

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Abstract

The purpose of this project was to assess the reliability of the cerebral mean transit time (MTT) obtained using perfusion-weighted MR imaging by comparing it with the MTT obtained when performing positron emission tomography (PET). Ten patients with chronic occlusive cerebrovascular disease were investigated. They had either unilateral internal carotid artery occlusion or middle cerebral artery occlusion. The regions-of-interest were placed in non-infarcted areas within the territory of the middle cerebral artery on the affected side. Control regions-of-interest were placed in mirrored regions of the contralateral side. Linear regression analyses were performed using the parameters of the MTT obtained with perfusion-weighted MR imaging and the MTT, cerebral blood flow, vascular reactivity, and oxygen extraction fraction obtained with PET. The respective MTTs of the affected and non-affected sides obtained with perfusion-weighted MR imaging versus those with PET were 7.3 ± 2.2 s and 6.0 ± 1.2 s versus 8.2 ± 3.0 s and 6.4 ± 1.7 s. The MTT obtained using perfusion-weighted MR imaging and PET demonstrated statistically significant correlation (r = 0.87, p < 0.0001). The MTT obtained with perfusion-weighted MR imaging correlated statistically with cerebral blood flow (r = -0.74, p < 0.001), vascular reactivity (r = -0.73, p < 0.001) and oxygen extraction fraction (r = 0.61, p < 0.01). Similarly, the MTT obtained using PET statistically correlated with cerebral blood flow (r = -0.78, p < 0.0001), vascular reactivity (r = -0.51, p < 0.05) and oxygen extraction fraction (r = 0.68, p < 0.01). The reliability of the MTT obtained using perfusion-weighted MR imaging appears to be approximately equal to that obtained with positron emission tomography.

Original languageEnglish
Pages (from-to)33-39
Number of pages7
JournalMagnetic Resonance Imaging
Volume21
Issue number1
DOIs
Publication statusPublished - Jan 1 2003

Fingerprint

Positron emission tomography
transit time
Positron-Emission Tomography
positrons
Perfusion
tomography
Imaging techniques
Cerebrovascular Circulation
Blood
blood flow
arteries
Oxygen
Blood Vessels
reactivity
occlusion
oxygen
Cerebrovascular Disorders
Linear regression
Middle Cerebral Artery Infarction
Middle Cerebral Artery

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

Reliability of mean transit time obtained using perfusion-weighted MR imaging; comparison with positron emission tomography. / Mihara, Futoshi; Kuwabara, Yasuo; Tanaka, Atsuo; Yoshiura, Takashi; Sasaki, Masayuki; Yoshida, Tsuyoshi; Masuda, Kouji; Matsushima, Toshio.

In: Magnetic Resonance Imaging, Vol. 21, No. 1, 01.01.2003, p. 33-39.

Research output: Contribution to journalArticle

Mihara, Futoshi ; Kuwabara, Yasuo ; Tanaka, Atsuo ; Yoshiura, Takashi ; Sasaki, Masayuki ; Yoshida, Tsuyoshi ; Masuda, Kouji ; Matsushima, Toshio. / Reliability of mean transit time obtained using perfusion-weighted MR imaging; comparison with positron emission tomography. In: Magnetic Resonance Imaging. 2003 ; Vol. 21, No. 1. pp. 33-39.
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