Remarkable effect of tris(4-fluorophenyl)phosphine oxide on the stabilization of chiral lanthanum complex catalysts. A new and practical protocol for the highly enantioselective epoxidation of conjugated enones

Rie Kino, Kazuhiro Daikai, Toshio Kawanami, Hiroshi Fumno, Junji Inanaga

    Research output: Contribution to journalArticlepeer-review

    30 Citations (Scopus)

    Abstract

    A new and efficient chiral catalyst system, lanthanumchiral BINOL-tris(4-fluorophenyl)phosphine oxidecumene hydroperoxide, was developed for the epoxidation of α,β-unsaturated ketones thus providing the corresponding epoxy ketones with excellent enantioselectivities (up to >99% ee) in good to excellent yields at room temperature.

    Original languageEnglish
    Pages (from-to)1822-1824
    Number of pages3
    JournalOrganic and Biomolecular Chemistry
    Volume2
    Issue number13
    DOIs
    Publication statusPublished - Jul 7 2004

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Physical and Theoretical Chemistry
    • Organic Chemistry

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