Remarkable enantioselectivity of molecularly imprinted TiO2 nano-thin films

Naoki Mizutani, Do Hyeon Yang, Roman Selyanchyn, Sergiy Korposh, Seung Woo Lee, Toyoki Kunitake

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

TiO2 nano-thin films with imprinted (R)- and (S)-enantiomers of propranolol, 1,1′-bi-naphthol, and 2-(4-isobutylphenyl)-propionic acid were fabricated on quartz plates by spin-coating their solutions with Ti(O-nBu)4 in a toluene-ethanol mixture (1:1, v/v). After template removal, the imprinted films showed better binding for original templates than to the corresponding enantiomers. The assessment of template incorporation, template removal, and re-binding was conducted through UV-vis measurements. Significant enhancement of enantioselectivity was achieved by optimization of the film thickness and by heat-treatment of the imprinted films. After subtraction of non-specific binding, the optimized films provided chiral recognition with the enantioselectivity of almost 100% for (R)-propranolol and 95% for (S)-propranolol.

Original languageEnglish
Pages (from-to)142-150
Number of pages9
JournalAnalytica Chimica Acta
Volume694
Issue number1-2
DOIs
Publication statusPublished - May 23 2011
Externally publishedYes

Fingerprint

Enantioselectivity
Propranolol
Enantiomers
Thin films
Quartz
Spin coating
Toluene
Film thickness
Ethanol
Hot Temperature
Heat treatment
toluene
ethanol
coating
titanium dioxide
quartz
acid
removal

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy

Cite this

Remarkable enantioselectivity of molecularly imprinted TiO2 nano-thin films. / Mizutani, Naoki; Yang, Do Hyeon; Selyanchyn, Roman; Korposh, Sergiy; Lee, Seung Woo; Kunitake, Toyoki.

In: Analytica Chimica Acta, Vol. 694, No. 1-2, 23.05.2011, p. 142-150.

Research output: Contribution to journalArticle

Mizutani, Naoki ; Yang, Do Hyeon ; Selyanchyn, Roman ; Korposh, Sergiy ; Lee, Seung Woo ; Kunitake, Toyoki. / Remarkable enantioselectivity of molecularly imprinted TiO2 nano-thin films. In: Analytica Chimica Acta. 2011 ; Vol. 694, No. 1-2. pp. 142-150.
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