Remarkably enhanced inhibitory effects of three-component hybrid liposomes including sugar surfactants on the growth of lung carcinoma cells

Ryuichi Ueoka; Yoko Matsumoto; Shigeru Hirose; Koichi Goto; Masahiro Goto; Shintaro Furusaki

doi:10.1248/cpb.50.563

Remarkably enhanced inhibitory effects of three-component hybrid liposomes including sugar surfactants on the growth of lung carcinoma cells

Ryuichi Ueoka, Yoko Matsumoto, Shigeru Hirose, Koichi Goto, Masahiro Goto, Shintaro Furusaki

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Sugar parts play important roles in recognizing molecules on the cell membranes. We successfully produced sugar-type micellar surfactants, lactonoalkylamide (LacC_n), for the first time. Spherical vesicles, three-component hybrid liposomes, were obtained after the sonication of the mixture of L-α-dimyristoylphosphatidylcholine (DMPC), Tween 20 and LacC_n (DMPC: Tween 20:LacC_n=65:7:28). It is noteworthy that high inhibitory effects of the three-component hybrid liposomes composed of DMPC, Tween 20, and LacCn (DMPC: Tween 20:LacC_n=65:7:28) on the growth of glioma (U251) and lung adenocarcinoma (RERF-LC-OK) cells were attained in vitro without any drug, although no significant inhibitory effects of any individual component (DMPC, Tween 20, LacC_n) or the two-component hybrid liposomes of DMPC and Tween 20 on the growth of tumor cells examined were obtained.

Original language	English
Pages (from-to)	563-565
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	50
Issue number	4
DOIs	https://doi.org/10.1248/cpb.50.563
Publication status	Published - Apr 1 2002

All Science Journal Classification (ASJC) codes

Chemistry(all)
Drug Discovery

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title = "Remarkably enhanced inhibitory effects of three-component hybrid liposomes including sugar surfactants on the growth of lung carcinoma cells",

abstract = "Sugar parts play important roles in recognizing molecules on the cell membranes. We successfully produced sugar-type micellar surfactants, lactonoalkylamide (LacCn), for the first time. Spherical vesicles, three-component hybrid liposomes, were obtained after the sonication of the mixture of L-α-dimyristoylphosphatidylcholine (DMPC), Tween 20 and LacCn (DMPC: Tween 20:LacCn=65:7:28). It is noteworthy that high inhibitory effects of the three-component hybrid liposomes composed of DMPC, Tween 20, and LacCn (DMPC: Tween 20:LacCn=65:7:28) on the growth of glioma (U251) and lung adenocarcinoma (RERF-LC-OK) cells were attained in vitro without any drug, although no significant inhibitory effects of any individual component (DMPC, Tween 20, LacCn) or the two-component hybrid liposomes of DMPC and Tween 20 on the growth of tumor cells examined were obtained.",

author = "Ryuichi Ueoka and Yoko Matsumoto and Shigeru Hirose and Koichi Goto and Masahiro Goto and Shintaro Furusaki",

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T1 - Remarkably enhanced inhibitory effects of three-component hybrid liposomes including sugar surfactants on the growth of lung carcinoma cells

AU - Ueoka, Ryuichi

AU - Matsumoto, Yoko

AU - Hirose, Shigeru

AU - Goto, Koichi

AU - Goto, Masahiro

AU - Furusaki, Shintaro

PY - 2002/4/1

Y1 - 2002/4/1

N2 - Sugar parts play important roles in recognizing molecules on the cell membranes. We successfully produced sugar-type micellar surfactants, lactonoalkylamide (LacCn), for the first time. Spherical vesicles, three-component hybrid liposomes, were obtained after the sonication of the mixture of L-α-dimyristoylphosphatidylcholine (DMPC), Tween 20 and LacCn (DMPC: Tween 20:LacCn=65:7:28). It is noteworthy that high inhibitory effects of the three-component hybrid liposomes composed of DMPC, Tween 20, and LacCn (DMPC: Tween 20:LacCn=65:7:28) on the growth of glioma (U251) and lung adenocarcinoma (RERF-LC-OK) cells were attained in vitro without any drug, although no significant inhibitory effects of any individual component (DMPC, Tween 20, LacCn) or the two-component hybrid liposomes of DMPC and Tween 20 on the growth of tumor cells examined were obtained.

AB - Sugar parts play important roles in recognizing molecules on the cell membranes. We successfully produced sugar-type micellar surfactants, lactonoalkylamide (LacCn), for the first time. Spherical vesicles, three-component hybrid liposomes, were obtained after the sonication of the mixture of L-α-dimyristoylphosphatidylcholine (DMPC), Tween 20 and LacCn (DMPC: Tween 20:LacCn=65:7:28). It is noteworthy that high inhibitory effects of the three-component hybrid liposomes composed of DMPC, Tween 20, and LacCn (DMPC: Tween 20:LacCn=65:7:28) on the growth of glioma (U251) and lung adenocarcinoma (RERF-LC-OK) cells were attained in vitro without any drug, although no significant inhibitory effects of any individual component (DMPC, Tween 20, LacCn) or the two-component hybrid liposomes of DMPC and Tween 20 on the growth of tumor cells examined were obtained.

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Remarkably enhanced inhibitory effects of three-component hybrid liposomes including sugar surfactants on the growth of lung carcinoma cells

Abstract

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