Remission of autoimmune neutropenia after development of Kawasaki disease

Seigo Okada; Shunji Hasegawa; Yasuo Suzuki; Takuya Ichimura; Hidenobu Kaneyasu; Maiko Shimomura; Midori Wakabayashi-Takahara; Kazuhiro Nakamura; Masao Kobayashi; Shouichi Ohga

doi:10.1111/ped.12701

Remission of autoimmune neutropenia after development of Kawasaki disease

Seigo Okada, Shunji Hasegawa, Yasuo Suzuki, Takuya Ichimura, Hidenobu Kaneyasu, Maiko Shimomura, Midori Wakabayashi-Takahara, Kazuhiro Nakamura, Masao Kobayashi, Shouichi Ohga

Research output: Contribution to journal › Article › peer-review

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Abstract

We report the second case of the association of Kawasaki disease (KD) and autoimmune neutropenia (AIN). A 21-month-old female diagnosed as having AIN of infancy developed a complete KD when severe neutropenia continued. The patient suffered from no coronary artery leions, and well responded to a single high-dose gamma-globulin therapy. The cytokine profile of the neutropenic infant was representative of the typical KD. Neutrophil counts notably increased during the convalescent phase of KD, and were then normalized forthwith. The prompt resolutions of KD and AIN paralleled the increase of circulating transforming growth factor (TGF)-β1 levels. The clinical course of the patient was contrasted to that of the first reported case of a patient who developed severe and refractory KD after the high dose granulocyte-colony stimulating factor (G-CSF) therapy.

Original language	English
Pages (from-to)	1012-1014
Number of pages	3
Journal	Pediatrics International
Volume	57
Issue number	5
DOIs	https://doi.org/10.1111/ped.12701
Publication status	Published - Oct 2015
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health

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10.1111/ped.12701

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title = "Remission of autoimmune neutropenia after development of Kawasaki disease",

abstract = "We report the second case of the association of Kawasaki disease (KD) and autoimmune neutropenia (AIN). A 21-month-old female diagnosed as having AIN of infancy developed a complete KD when severe neutropenia continued. The patient suffered from no coronary artery leions, and well responded to a single high-dose gamma-globulin therapy. The cytokine profile of the neutropenic infant was representative of the typical KD. Neutrophil counts notably increased during the convalescent phase of KD, and were then normalized forthwith. The prompt resolutions of KD and AIN paralleled the increase of circulating transforming growth factor (TGF)-β1 levels. The clinical course of the patient was contrasted to that of the first reported case of a patient who developed severe and refractory KD after the high dose granulocyte-colony stimulating factor (G-CSF) therapy.",

author = "Seigo Okada and Shunji Hasegawa and Yasuo Suzuki and Takuya Ichimura and Hidenobu Kaneyasu and Maiko Shimomura and Midori Wakabayashi-Takahara and Kazuhiro Nakamura and Masao Kobayashi and Shouichi Ohga",

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AU - Okada, Seigo

AU - Hasegawa, Shunji

AU - Suzuki, Yasuo

AU - Ichimura, Takuya

AU - Kaneyasu, Hidenobu

AU - Shimomura, Maiko

AU - Wakabayashi-Takahara, Midori

AU - Nakamura, Kazuhiro

AU - Kobayashi, Masao

AU - Ohga, Shouichi

PY - 2015/10

Y1 - 2015/10

N2 - We report the second case of the association of Kawasaki disease (KD) and autoimmune neutropenia (AIN). A 21-month-old female diagnosed as having AIN of infancy developed a complete KD when severe neutropenia continued. The patient suffered from no coronary artery leions, and well responded to a single high-dose gamma-globulin therapy. The cytokine profile of the neutropenic infant was representative of the typical KD. Neutrophil counts notably increased during the convalescent phase of KD, and were then normalized forthwith. The prompt resolutions of KD and AIN paralleled the increase of circulating transforming growth factor (TGF)-β1 levels. The clinical course of the patient was contrasted to that of the first reported case of a patient who developed severe and refractory KD after the high dose granulocyte-colony stimulating factor (G-CSF) therapy.

AB - We report the second case of the association of Kawasaki disease (KD) and autoimmune neutropenia (AIN). A 21-month-old female diagnosed as having AIN of infancy developed a complete KD when severe neutropenia continued. The patient suffered from no coronary artery leions, and well responded to a single high-dose gamma-globulin therapy. The cytokine profile of the neutropenic infant was representative of the typical KD. Neutrophil counts notably increased during the convalescent phase of KD, and were then normalized forthwith. The prompt resolutions of KD and AIN paralleled the increase of circulating transforming growth factor (TGF)-β1 levels. The clinical course of the patient was contrasted to that of the first reported case of a patient who developed severe and refractory KD after the high dose granulocyte-colony stimulating factor (G-CSF) therapy.

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Remission of autoimmune neutropenia after development of Kawasaki disease

Abstract

All Science Journal Classification (ASJC) codes

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