Removal of organic solvent from antibiotics with supercritical carbon dioxide

Masamichi Kamihira; Masayuki Taniguchi; Takeshi Kobayashi

doi:10.1016/0385-6380(87)90067-7

Removal of organic solvent from antibiotics with supercritical carbon dioxide

Masamichi Kamihira, Masayuki Taniguchi, Takeshi Kobayashi

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Organic solvents were rapidly extracted from penicillin G potassium and streptomycin sulfate with supercritical carbon dioxide (SC-CO₂) at 200 atm and 35°C without loss of antibiotic activities. The amounts of organic solvents remaining in the antibiotics depended upon pressure and temperature for a given extraction time. A semilogarithmic plot of remaining amounts of organic solvents against extraction time gave a straight line in the early extraction stage, allowing prediction of the extraction time required for decreasing amounts of organic solvent. The addition of water as an entrainer to SC-CO₂ resulted in a significant increase in extraction rates.

Original language	English
Pages (from-to)	71-75
Number of pages	5
Journal	Journal of Fermentation Technology
Volume	65
Issue number	1
DOIs	https://doi.org/10.1016/0385-6380(87)90067-7
Publication status	Published - Jan 1 1987
Externally published	Yes

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author = "Masamichi Kamihira and Masayuki Taniguchi and Takeshi Kobayashi",

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AU - Kobayashi, Takeshi

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AB - Organic solvents were rapidly extracted from penicillin G potassium and streptomycin sulfate with supercritical carbon dioxide (SC-CO2) at 200 atm and 35°C without loss of antibiotic activities. The amounts of organic solvents remaining in the antibiotics depended upon pressure and temperature for a given extraction time. A semilogarithmic plot of remaining amounts of organic solvents against extraction time gave a straight line in the early extraction stage, allowing prediction of the extraction time required for decreasing amounts of organic solvent. The addition of water as an entrainer to SC-CO2 resulted in a significant increase in extraction rates.

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Removal of organic solvent from antibiotics with supercritical carbon dioxide

Abstract

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