Renal cell carcinoma with rhabdoid-like features lack intracytoplasmic inclusion bodies and show aggressive behavior

Masaaki Sugimoto, Kenichi Kouhashi, Kentaro Kuroiwa, Tatsuro Abe, Yuichi Yamada, masaki shiota, Kenjiro Imada, Seiji Naito, Yoshinao Oda

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In renal cell carcinoma (RCC), tumor cells with rhabdoid features are characterized by eccentric nuclei, prominent nucleoli, and eosinophilic cytoplasm with intracytoplasmic inclusion bodies. In RCC, tumor cells have also been observed resembling rhabdomyoblasts or rhabdoid but without intracytoplasmic inclusion bodies, and here, we defined these rhabdoid-like features of these cells. To this end, we studied a series of clear cell RCC (ccRCC) with rhabdoid features and compared them with a series of ccRCC with rhabdoid-like features to clarify the differences in the immunohistochemical profile and biological behavior. From 695 cases of ccRCC (80.8% of all RCCs), 18 cases with rhabdoid features (2.1% of all RCCs) and 25 cases with rhabdoid-like features (2.9% of all RCCs) were investigated. The 5-year survival rate for ccRCC with rhabdoid features was 44.7% and for ccRCC with rhabdoid-like features 30.3%. Although ccRCC with rhabdoid features showed immunohistochemical co-expression of epithelial markers and vimentin as seen in malignant rhabdoid tumors, ccRCC with rhabdoid-like features showed no such co-expression. Multivariate analyses of cancer-specific survival revealed that perinephric tissues invasion was an independent prognostic factor in ccRCC with rhabdoid features (p = 0.0253) but not in ccRCC with rhabdoid-like features. In summary, although their prognosis is similar, the marker profile and pattern of extension of ccRCC with rhabdoid-like is different from that of ccRCC with rhabdoid features. Therefore, ccRCC with rhabdoidlike features should be distinguished from ccRCC with rhabdoid features.

Original languageEnglish
Pages (from-to)357-367
Number of pages11
JournalVirchows Archiv
Volume468
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

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Inclusion Bodies
Renal Cell Carcinoma
Clear-cell metastatic renal cell carcinoma
Rhabdoid Tumor
Neoplasms
Vimentin
Cytoplasm
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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Renal cell carcinoma with rhabdoid-like features lack intracytoplasmic inclusion bodies and show aggressive behavior. / Sugimoto, Masaaki; Kouhashi, Kenichi; Kuroiwa, Kentaro; Abe, Tatsuro; Yamada, Yuichi; shiota, masaki; Imada, Kenjiro; Naito, Seiji; Oda, Yoshinao.

In: Virchows Archiv, Vol. 468, No. 3, 01.03.2016, p. 357-367.

Research output: Contribution to journalArticle

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abstract = "In renal cell carcinoma (RCC), tumor cells with rhabdoid features are characterized by eccentric nuclei, prominent nucleoli, and eosinophilic cytoplasm with intracytoplasmic inclusion bodies. In RCC, tumor cells have also been observed resembling rhabdomyoblasts or rhabdoid but without intracytoplasmic inclusion bodies, and here, we defined these rhabdoid-like features of these cells. To this end, we studied a series of clear cell RCC (ccRCC) with rhabdoid features and compared them with a series of ccRCC with rhabdoid-like features to clarify the differences in the immunohistochemical profile and biological behavior. From 695 cases of ccRCC (80.8{\%} of all RCCs), 18 cases with rhabdoid features (2.1{\%} of all RCCs) and 25 cases with rhabdoid-like features (2.9{\%} of all RCCs) were investigated. The 5-year survival rate for ccRCC with rhabdoid features was 44.7{\%} and for ccRCC with rhabdoid-like features 30.3{\%}. Although ccRCC with rhabdoid features showed immunohistochemical co-expression of epithelial markers and vimentin as seen in malignant rhabdoid tumors, ccRCC with rhabdoid-like features showed no such co-expression. Multivariate analyses of cancer-specific survival revealed that perinephric tissues invasion was an independent prognostic factor in ccRCC with rhabdoid features (p = 0.0253) but not in ccRCC with rhabdoid-like features. In summary, although their prognosis is similar, the marker profile and pattern of extension of ccRCC with rhabdoid-like is different from that of ccRCC with rhabdoid features. Therefore, ccRCC with rhabdoidlike features should be distinguished from ccRCC with rhabdoid features.",
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AU - Kouhashi, Kenichi

AU - Kuroiwa, Kentaro

AU - Abe, Tatsuro

AU - Yamada, Yuichi

AU - shiota, masaki

AU - Imada, Kenjiro

AU - Naito, Seiji

AU - Oda, Yoshinao

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