Repeated adenosine pre-treatment potentiates the acute effect of methamphetamine in rats

A. Kawashimo, T. Shimazoe, A. Yoshimatsu, S. Watanabe

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Adenosine was intraperitoneally (i.p.) injected to Wistar rats every 3 days with a total of 5 administrations. After a 7-day withdrawal, the animals were challenged with methamphetamine (0.5 mg/kg, i.p.). The effect of methamphetamine on locomotor activity was significantly potentiated by repeated adenosine pre-treatment. Moreover, methamphetamine-induced dopamine release was also increased in the striatum. Methamphetamine-induced hyperactivity and dopamine release were significantly potentiated by repeated pre-treatment of an adenosine A1 agonist, N6-cyclohexyladenosine (0.5 mg/kg, i.p.). These results suggest that the acute effect of methamphetamine is potentiated by repeated pre-treatment of adenosine via adenosine A1 receptors.

Original languageEnglish
Pages (from-to)78-81
Number of pages4
JournalJapanese Journal of Pharmacology
Volume84
Issue number1
DOIs
Publication statusPublished - 2000

All Science Journal Classification (ASJC) codes

  • Pharmacology

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