Repeated Administration of Amitriptyline Reduces Oxaliplatin-Induced Mechanical Allodynia in Rats

Hikaru Sada, Nobuaki Egashira, Soichiro Ushio, Takehiro Kawashiri, Masafumi Shirahama, Ryozo Oishi

Research output: Contribution to journalArticle

Abstract

Oxaliplatin is a key drug in the treatment of colorectal cancer, but it causes acute and chronic neuropathies in patients. Amitriptyline has widely been used in patients with painful neuropathy. In this study, we investigated the effect of amitriptyline on the oxaliplatin-induced neuropathy in rats. Repeated administration of amitriptyline (5 and 10 mg/kg, p.o., once a day) reduced the oxaliplatin-induced mechanical allodynia but not cold hyperalgesia and reversed the oxaliplatin-induced increase in the expression of NR2B protein and mRNA in rat spinal cord. These results suggest that amitriptyline is useful for the treatment of oxaliplatin-induced neuropathy clinically.
Original languageEnglish
Pages (from-to)547-551
Number of pages5
JournalJournal of Pharmacological Sciences
Volume118
Issue number4
DOIs
Publication statusPublished - Apr 20 2012

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