Report of the committee for establishment of the response evaluation criteria of antifungal therapy for oral candidiasis

Yoichi Nakagawa, Takahiro Oneyama, Haruhiko Terai, Akihiro Kanekawa, Hiroshi Iwabuchi, Satoshi Miyake, Isao Hasegawa, Masanori Nishikawa, Hideki Nakayama, Satoshi Nishimura, Jun Nosuke Hayashida, Kenichi Saito, Kojiro Onizawa, Masayuki Fukuda, Kanae Niimi, Takahiko Shibahara, Yoshinori Jinbu, Hitoshi Kawamata, Akihisa Tsurumoto, Tazuko SatohKatsunori Ishibashi, Akihiro Kaneko, Takahiro Miyasaka, Yoshiaki Kamikawa, Tomoari Kuriyama, Nobuko Maeda, Shoji Yamada, Tsutomu Sato, Fumiaki Ikeda, Intetsu Kobayashi

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The purpose of the study was to establish the response evaluation criteria of antifungal agents for oral candidiasis. Methods: A multicenter open-label trial was conducted. The patients with oral candidiasis were treated by an antifungal agent, itraconazole, and the response to the agent was evaluated according to the protocoL A multiple regression analysis was employed to examine the relative contribution of clinical signs and symptoms, including redness, white papules, atrophy of the papilla of the tongue, pain and soreness to the global evaluation of the responses judged by the attending physician. The global evaluation of the responses was rated as markedly improved, moderately improved or unchanged. Results: The multiple regression analysis showed that redness of the tongue and palate, white papules on the tongue, atrophy of the papillae of the tongue, and pain were associated with the global evaluation of the responses judged by the attending physician. Conclusion: Evaluation of these signs and symptoms could provide useful response information about antifungal therapy for oral candidiasis patients. Further studies will therefore be needed to verify the results of the present study.

Original languageEnglish
Pages (from-to)30-40
Number of pages11
JournalORAL THERAPEUTICS AND PHARMACOLOGY
Volume30
Issue number1
Publication statusPublished - Apr 2011

All Science Journal Classification (ASJC) codes

  • Dentistry(all)
  • Pharmacology
  • Pharmacology (medical)

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