Reprogramming of gastrointestinal cancer cells

DyahLaksmi Dewi, Hideshi Ishii, Naotsugu Haraguchi, Shimpei Nishikawa, Yoshihiro Kano, Takahito Fukusumi, Katsuya Ohta, Susumu Miyazaki, Miyuki Ozaki, Daisuke Sakai, Taroh Satoh, Hiroaki Nagano, Yuichiro Doki, Masaki Mori

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Cell reprogramming reverts cells to multipotent, preprogrammed states by re-establishing epigenetic markers. It can also induce considerable malignant phenotype modification. Because key events in cancer relapse and metastasis, including epithelial-mesenchymal transition phenotypes, are regulated primarily by reversible and transient epigenetic modifications rather than the accumulation of irreversible and stable genetic abnormalities, studying dynamic mechanisms regulating these biological processes is important. Transcription factors for induced pluripotent stem cells and non-coding microRNAs allow pluripotent phenotype induction. We present the current knowledge of the possible applications of cell reprogramming in reducing aggressive phenotype expression, which can induce tumor cell hibernation and maintain appropriate phenotypes, thereby minimizing relapse and metastasis after surgical resection of gastrointestinal cancer.

Original languageEnglish
Pages (from-to)393-399
Number of pages7
JournalCancer Science
Volume103
Issue number3
DOIs
Publication statusPublished - Jan 18 2012
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology

Cite this

Dewi, D., Ishii, H., Haraguchi, N., Nishikawa, S., Kano, Y., Fukusumi, T., ... Mori, M. (2012). Reprogramming of gastrointestinal cancer cells. Cancer Science, 103(3), 393-399. https://doi.org/10.1111/j.1349-7006.2011.02184.x