Requirement for CD8 β chain in positive selection of CD8-lineage T cells

Kei Ichi Nakayama, Keiko Nakayama, Izumi Negishi, Keisuke Kuida, Marjorie C. Louie, Osami Kanagawa, Hiromitsu Nakauchi, Dennis Y. Loh

Research output: Contribution to journalArticle

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Abstract

CD8 is either an αα homodimer or an αβ heterodimer, although most peripheral CD8-lineage T cells express only the CD8αβ heterodimer. The physiological function of CD8β was elucidated with mice that were chimeric for the homozygous disruption of the CD8β gene. The CD8β-/- T cells developed normally to CD4+CD8 + stage, but did not efficiently differentiate further, which resulted in few peripheral CD8+ T cells. The number of peripheral CD8+ T cells was restored by transfer of an exogenous CD8β gene into CD8β-deficient T cells. Thus, CD8β is necessary for the maturation of CD8+ T cells.

Original languageEnglish
Pages (from-to)1131-1133
Number of pages3
JournalScience
Volume263
Issue number5150
DOIs
Publication statusPublished - Jan 1 1994
Externally publishedYes

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T-Lymphocytes
Genes

All Science Journal Classification (ASJC) codes

  • General

Cite this

Nakayama, K. I., Nakayama, K., Negishi, I., Kuida, K., Louie, M. C., Kanagawa, O., ... Loh, D. Y. (1994). Requirement for CD8 β chain in positive selection of CD8-lineage T cells. Science, 263(5150), 1131-1133. https://doi.org/10.1126/science.8108731

Requirement for CD8 β chain in positive selection of CD8-lineage T cells. / Nakayama, Kei Ichi; Nakayama, Keiko; Negishi, Izumi; Kuida, Keisuke; Louie, Marjorie C.; Kanagawa, Osami; Nakauchi, Hiromitsu; Loh, Dennis Y.

In: Science, Vol. 263, No. 5150, 01.01.1994, p. 1131-1133.

Research output: Contribution to journalArticle

Nakayama, KI, Nakayama, K, Negishi, I, Kuida, K, Louie, MC, Kanagawa, O, Nakauchi, H & Loh, DY 1994, 'Requirement for CD8 β chain in positive selection of CD8-lineage T cells', Science, vol. 263, no. 5150, pp. 1131-1133. https://doi.org/10.1126/science.8108731
Nakayama KI, Nakayama K, Negishi I, Kuida K, Louie MC, Kanagawa O et al. Requirement for CD8 β chain in positive selection of CD8-lineage T cells. Science. 1994 Jan 1;263(5150):1131-1133. https://doi.org/10.1126/science.8108731
Nakayama, Kei Ichi ; Nakayama, Keiko ; Negishi, Izumi ; Kuida, Keisuke ; Louie, Marjorie C. ; Kanagawa, Osami ; Nakauchi, Hiromitsu ; Loh, Dennis Y. / Requirement for CD8 β chain in positive selection of CD8-lineage T cells. In: Science. 1994 ; Vol. 263, No. 5150. pp. 1131-1133.
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AU - Nakauchi, Hiromitsu

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