Requirement of CD30 expression on CD4 T cells in the pathogenesis of experimental autoimmune encephalomyelitis

Koji Shinoda, Xun Sun, Akiko Oyamada, Hisakata Yamada, Jun-Ichi Kira, Yasunobu Yoshikai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

CD30, a member of the tumor necrosis factor receptor superfamily, is expressed preferentially by effector or memory helper T cells. Here we show that experimental autoimmune encephalomyelitis (EAE) is ameliorated with markedly reduced induction of antigen-specific Th1 and Th17 cells in CD30 knockout mice. Passive EAE indicated that CD30 on non-hematopoietic parenchymal cell is not required and mixed bone marrow chimera experiments revealed that CD30 signaling on CD4 T cells amplified the development of antigen-specific and encephalitogenic CD4 T cells. Thus, CD30 expression on CD4 T cells is critically involved in the pathogenesis of central nervous system autoimmunity.

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalJournal of Neuroimmunology
Volume291
DOIs
Publication statusPublished - Feb 15 2016

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Autoimmune Experimental Encephalomyelitis
T-Lymphocytes
Th17 Cells
Antigens
Th1 Cells
Tumor Necrosis Factor Receptors
Helper-Inducer T-Lymphocytes
Autoimmunity
Knockout Mice
Central Nervous System
Bone Marrow

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Requirement of CD30 expression on CD4 T cells in the pathogenesis of experimental autoimmune encephalomyelitis. / Shinoda, Koji; Sun, Xun; Oyamada, Akiko; Yamada, Hisakata; Kira, Jun-Ichi; Yoshikai, Yasunobu.

In: Journal of Neuroimmunology, Vol. 291, 15.02.2016, p. 39-45.

Research output: Contribution to journalArticle

Shinoda, Koji ; Sun, Xun ; Oyamada, Akiko ; Yamada, Hisakata ; Kira, Jun-Ichi ; Yoshikai, Yasunobu. / Requirement of CD30 expression on CD4 T cells in the pathogenesis of experimental autoimmune encephalomyelitis. In: Journal of Neuroimmunology. 2016 ; Vol. 291. pp. 39-45.
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