Research trend for pathogenesis of sarcoidosis--streptococcal cell wall component (SCW)

N. Shigematsu, K. Kido, T. Ikeda, N. Kamikawaji, Takehiko Sasazuki

Research output: Contribution to journalReview article

Abstract

In search for the pathogenetic factors, we have found the following: 1) Chronic bacterial foci in the upper airway is showing adverse effect on clinical course of sarcoidosis. Alpha-streptococcus is mainly detected. 2) The prevalence of chronic tonsillitis in sarcoidosis is high if compared with that among Japanese adults examined by rhinolaryngologists. 3) The development of noncaseating epithelioid granulomas is reported after injections of an aqueous suspension of alpha-streptococcal cell wall (SCW) fragments into susceptible Lewis female rats. 4) Both protracted clinical course in sarcoidosis and higher responsiveness to SCW antigen are related to HLA-DR4, DR9 and DRw8. These results suggest that in sarcoidosis significance of persistence of antigen in upper respiratory tract and the significant correlation between SCW binding to Ia and immunogenicity, implicated by Schaeffer's, are seen.

Original languageEnglish
Pages (from-to)1498-1502
Number of pages5
JournalNippon rinsho. Japanese journal of clinical medicine
Volume52
Issue number6
Publication statusPublished - Jan 1 1994
Externally publishedYes

Fingerprint

Cellular Structures
Sarcoidosis
Cell Wall
Research
HLA-DR4 Antigen
Antigens
Tonsillitis
Streptococcus
Granuloma
Respiratory System
Suspensions
Injections

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Shigematsu, N., Kido, K., Ikeda, T., Kamikawaji, N., & Sasazuki, T. (1994). Research trend for pathogenesis of sarcoidosis--streptococcal cell wall component (SCW). Nippon rinsho. Japanese journal of clinical medicine, 52(6), 1498-1502.

Research trend for pathogenesis of sarcoidosis--streptococcal cell wall component (SCW). / Shigematsu, N.; Kido, K.; Ikeda, T.; Kamikawaji, N.; Sasazuki, Takehiko.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 52, No. 6, 01.01.1994, p. 1498-1502.

Research output: Contribution to journalReview article

Shigematsu, N, Kido, K, Ikeda, T, Kamikawaji, N & Sasazuki, T 1994, 'Research trend for pathogenesis of sarcoidosis--streptococcal cell wall component (SCW)', Nippon rinsho. Japanese journal of clinical medicine, vol. 52, no. 6, pp. 1498-1502.
Shigematsu, N. ; Kido, K. ; Ikeda, T. ; Kamikawaji, N. ; Sasazuki, Takehiko. / Research trend for pathogenesis of sarcoidosis--streptococcal cell wall component (SCW). In: Nippon rinsho. Japanese journal of clinical medicine. 1994 ; Vol. 52, No. 6. pp. 1498-1502.
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