Resected case of co-existing combined hepatocellular-cholangiocarcinoma and cholangiolocellular carcinoma in the same segment of normal liver

Michiko Aono, Hironori Ochi, Ryo Yano, Kaori Sato, Yuusuke Okujima, Nobuaki Azemoto, Toshie Mashiba, Tomoyuki Yokota, Yumi Ooshiro, Yuji Soejima, Takashi Nishizaki, Kouji Joko

Research output: Contribution to journalArticlepeer-review

Abstract

Here, we report a resected case of co-existing combined hepatocellular-cholangiocarcinoma (cHC-CC) and cholangiolocellular carcinoma (CoCC) in the same segment of the liver. A 75-year-old woman was referred and admitted to our hospital for further examination of two liver tumors. Contrast-enhanced ultrasonography, dynamic computed tomography, Gd-EOB-DTPA-enhanced magnetic resonance imaging, and abdominal angiography revealed the two tumors (diameter: tumor A, 20 mm and tumor B, 11 mm). A dynamic study of the tumors showed that in the early phase, tumor A showed peritumoral enhancement and tumor B showed hypervascu-larity. However, in the portal and equilibrated phases, both tumors were homogeneously enhanced. Tumor A was radiologically diagnosed as an intrahepatic CC and tumor B as CoCC. Subsequently, S4 and S5a segmentec-tomy was performed, and tumors A and B were pathologically diagnosed as cHC-CC and CoCC, respectively. No recurrence was observed in the patient after postoperative 2 years 6 months. To the best of our knowledge, cases in which cHC-CC and CoCC co-exist in the same segment are extremely rare, which makes the present case valuable.

Original languageEnglish
Pages (from-to)179-188
Number of pages10
JournalActa Hepatologica Japonica
Volume60
Issue number6
DOIs
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Hepatology

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