Reserved Sertoli cell function in the hypogonadic male patients with myotonic dystrophy.

X. Y. Lou, Y. Nishi, M. Haji, Y. Antoku, S. Tanaka, S. Ikuyama, T. Yanase, R. Takayanagi, H. Nawata

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

To clarify the Sertoli cell and Leydig cell function in hypogonadic male patients with myotonic dystrophy (DM), serum concentrations of inhibin, total testosterone (TT), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were measured by radioimmunoassay in 6 male DM patients (41 to 56 years old, 47.7 +/- 5.05 years old) and compared with those in normal adult men. In 116 healthy men aged from 24 to 92 years, serum inhibin and TT levels decreased and serum FSH and LH concentrations increased with advancing age. There was an inverse correlation between serum inhibin and FSH. These results support the concept of negative feedback regulation system of FSH secretion by inhibin. Male DM patients showed significantly lower serum TT and higher concentrations of FSH and LH, compared with the age-matched 39 normal adult men (49-59 years old, 48.2 +/- 6.14 years old). However, there was no significant difference in serum inhibin levels between the patients and normal counterparts. These results indicate that the Sertoli cell function is reserved in male DM patient, although the Leydig cell function is impaired. It is also suggested that in these patients a negative feedback control system between inhibin and FSH may be disordered to some extent.

Original languageEnglish
Pages (from-to)168-174
Number of pages7
JournalFukuoka igaku zasshi = Hukuoka acta medica
Volume85
Issue number5
Publication statusPublished - May 1994

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Myotonic Dystrophy
Inhibins
Sertoli Cells
Follicle Stimulating Hormone
Luteinizing Hormone
Serum
Testosterone
Leydig Cells
Radioimmunoassay

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lou, X. Y., Nishi, Y., Haji, M., Antoku, Y., Tanaka, S., Ikuyama, S., ... Nawata, H. (1994). Reserved Sertoli cell function in the hypogonadic male patients with myotonic dystrophy. Fukuoka igaku zasshi = Hukuoka acta medica, 85(5), 168-174.

Reserved Sertoli cell function in the hypogonadic male patients with myotonic dystrophy. / Lou, X. Y.; Nishi, Y.; Haji, M.; Antoku, Y.; Tanaka, S.; Ikuyama, S.; Yanase, T.; Takayanagi, R.; Nawata, H.

In: Fukuoka igaku zasshi = Hukuoka acta medica, Vol. 85, No. 5, 05.1994, p. 168-174.

Research output: Contribution to journalArticle

Lou, XY, Nishi, Y, Haji, M, Antoku, Y, Tanaka, S, Ikuyama, S, Yanase, T, Takayanagi, R & Nawata, H 1994, 'Reserved Sertoli cell function in the hypogonadic male patients with myotonic dystrophy.', Fukuoka igaku zasshi = Hukuoka acta medica, vol. 85, no. 5, pp. 168-174.
Lou XY, Nishi Y, Haji M, Antoku Y, Tanaka S, Ikuyama S et al. Reserved Sertoli cell function in the hypogonadic male patients with myotonic dystrophy. Fukuoka igaku zasshi = Hukuoka acta medica. 1994 May;85(5):168-174.
Lou, X. Y. ; Nishi, Y. ; Haji, M. ; Antoku, Y. ; Tanaka, S. ; Ikuyama, S. ; Yanase, T. ; Takayanagi, R. ; Nawata, H. / Reserved Sertoli cell function in the hypogonadic male patients with myotonic dystrophy. In: Fukuoka igaku zasshi = Hukuoka acta medica. 1994 ; Vol. 85, No. 5. pp. 168-174.
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