Resistance to anticancer drugs of well differentiated gastric adenocarcinoma with venous invasion

Y. Sakaguchi, H. Anai, S. Kohnoe, Y. Emi, T. Kusumoto, Yoshihiko Maehara, K. Sugimachi

Research output: Contribution to journalArticle

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Abstract

A comparison of the chemosensitivity of well-differentiated human gastric cancer tissues was made between histological venous invasion positive (v (+)) and negative (v (-)) tissues, using the succinate dehydrogenase inhibition (SDI) test. These tissues obtained at the time of surgery were exposed to six anticancer drugs: carboquone (CQ), adriamycin (ADM), mitomycin C (MMC), aclacinomycin A (ACR), cisplatin (DDP) and 5-fluorouracil (5-FU). Chemosensitivity was judged to be positive when the succinate dehydrogenase (SD) activity of the drug exposed cells decreased to below 50% of that of control cells. Decrease in the SD activity was more apparent in the v(-) tissues than in the v(+) tissues, exposed to the anticancer drugs and in particular to ADM (P < 0.01), MMC (P < 0.02) and DDP (P < 0.05). The sensitivity rates to all six anticancer drugs were lower in the v(+) tissues. The resistance rates to all drugs tested were 0% in the v(-) tissues, but 21% in the v(+) tissues. In light of these observations, patients with gastric cancer of the well differentiated type and the histological venous invasion, will probably show a less positive response to cancer chemotherapy.

Original languageEnglish
Pages (from-to)142-145
Number of pages4
JournalEuropean Journal of Surgical Oncology
Volume18
Issue number2
Publication statusPublished - Jan 1 1992

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Stomach
Adenocarcinoma
Pharmaceutical Preparations
Succinate Dehydrogenase
Mitomycin
Doxorubicin
Stomach Neoplasms
Carbazilquinone
Aclarubicin
Fluorouracil
Cisplatin
Drug Therapy
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Sakaguchi, Y., Anai, H., Kohnoe, S., Emi, Y., Kusumoto, T., Maehara, Y., & Sugimachi, K. (1992). Resistance to anticancer drugs of well differentiated gastric adenocarcinoma with venous invasion. European Journal of Surgical Oncology, 18(2), 142-145.

Resistance to anticancer drugs of well differentiated gastric adenocarcinoma with venous invasion. / Sakaguchi, Y.; Anai, H.; Kohnoe, S.; Emi, Y.; Kusumoto, T.; Maehara, Yoshihiko; Sugimachi, K.

In: European Journal of Surgical Oncology, Vol. 18, No. 2, 01.01.1992, p. 142-145.

Research output: Contribution to journalArticle

Sakaguchi, Y, Anai, H, Kohnoe, S, Emi, Y, Kusumoto, T, Maehara, Y & Sugimachi, K 1992, 'Resistance to anticancer drugs of well differentiated gastric adenocarcinoma with venous invasion', European Journal of Surgical Oncology, vol. 18, no. 2, pp. 142-145.
Sakaguchi Y, Anai H, Kohnoe S, Emi Y, Kusumoto T, Maehara Y et al. Resistance to anticancer drugs of well differentiated gastric adenocarcinoma with venous invasion. European Journal of Surgical Oncology. 1992 Jan 1;18(2):142-145.
Sakaguchi, Y. ; Anai, H. ; Kohnoe, S. ; Emi, Y. ; Kusumoto, T. ; Maehara, Yoshihiko ; Sugimachi, K. / Resistance to anticancer drugs of well differentiated gastric adenocarcinoma with venous invasion. In: European Journal of Surgical Oncology. 1992 ; Vol. 18, No. 2. pp. 142-145.
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