Resistance to autoimmune thyroid disease is associated with HLA-DQ

Hajime Tamai, Akinori Kimura, Rui Ping Dong, Sunao Matsubayashi, Kanji Kuma, Shigenobu Nagataki, Takehiko Sasazuki

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Genotypes of DQA1 and DQB1 genes were determined by polymerase chain reaction followed by dot blot hybridization with sequence-specific oligonucleotide probes in 105 patients with goitrous autoimmune thyroiditis (Hashimoto's thyroiditis) and in 67 patients with Graves' disease to investigate whether specific DQ alleles were associated with susceptibility or resistance to autoimmune thyroid diseases. Hashimoto's thyroiditis was found to be negatively associated with DQA1*0102 and DQB1*0602 whereas Graves' disease showed a negative association with DQB1*0501. No strongly positive association with a specific DQ allele was found in either disease. These results suggest that the HLA-DQ gene may be a genetic marker for resistance to autoimmune thyroid diseases.

Original languageEnglish
Pages (from-to)94-97
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume78
Issue number1
DOIs
Publication statusPublished - Jan 1 1994

Fingerprint

HLA-DQ Antigens
Hashimoto Disease
Graves Disease
Thyroid Diseases
Autoimmune Diseases
Alleles
Autoimmune Thyroiditis
Oligonucleotide Probes
Genetic Markers
Genes
Genotype
Polymerase Chain Reaction
Polymerase chain reaction
HLA-DQB1 antigen

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Tamai, H., Kimura, A., Dong, R. P., Matsubayashi, S., Kuma, K., Nagataki, S., & Sasazuki, T. (1994). Resistance to autoimmune thyroid disease is associated with HLA-DQ. Journal of Clinical Endocrinology and Metabolism, 78(1), 94-97. https://doi.org/10.1210/jc.78.1.94

Resistance to autoimmune thyroid disease is associated with HLA-DQ. / Tamai, Hajime; Kimura, Akinori; Dong, Rui Ping; Matsubayashi, Sunao; Kuma, Kanji; Nagataki, Shigenobu; Sasazuki, Takehiko.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 78, No. 1, 01.01.1994, p. 94-97.

Research output: Contribution to journalArticle

Tamai, H, Kimura, A, Dong, RP, Matsubayashi, S, Kuma, K, Nagataki, S & Sasazuki, T 1994, 'Resistance to autoimmune thyroid disease is associated with HLA-DQ', Journal of Clinical Endocrinology and Metabolism, vol. 78, no. 1, pp. 94-97. https://doi.org/10.1210/jc.78.1.94
Tamai, Hajime ; Kimura, Akinori ; Dong, Rui Ping ; Matsubayashi, Sunao ; Kuma, Kanji ; Nagataki, Shigenobu ; Sasazuki, Takehiko. / Resistance to autoimmune thyroid disease is associated with HLA-DQ. In: Journal of Clinical Endocrinology and Metabolism. 1994 ; Vol. 78, No. 1. pp. 94-97.
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