Resistance to gastrointestinal proteases of the short chain peptides having reductive effect in blood pressure

Eiji Seki, Katsuhiro Osajima, Hiroshi Matsufuji, Toshiro Matsui, Yutaka Osajima

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The peptides with average molecular weight 315 were prepared from sardine proteins by Bacillus licheniformis alkaline proteases. The short chain peptides had no bitter taste and little fish flavor. The short chain peptides showed the potent angiotensin I-converting enzyme (ACE) inhibitory activity, which was high resistance to the hydrolysis by any digestive proteases. ACE inhibitory activity of short chain peptides didn't change by the pig intestinal fluid after pepsin digestion. Compared with the long chain peptides in sardine muscle hydrolyzate prepared by digestive proteases, inhibitory activities of various digest were weaker than that of the short chain peptides derived from alkaline proteases hydrolyzate. The short chain peptides were assayed in spontaneously hypertensive rats and found to reduce on blood pressure.

Original languageEnglish
Pages (from-to)520-525
Number of pages6
JournalNippon Shokuhin Kagaku Kogaku Kaishi
Volume43
Issue number5
DOIs
Publication statusPublished - Jan 1 1996

Fingerprint

blood pressure
Peptide Hydrolases
proteinases
peptides
Blood Pressure
Peptides
peptidyl-dipeptidase A
sardines
Peptidyl-Dipeptidase A
Bacillus licheniformis
Pepsin A
Inbred SHR Rats
pepsin
Digestion
Fishes
Hydrolysis
Swine
flavor
hydrolysis
Molecular Weight

All Science Journal Classification (ASJC) codes

  • Food Science

Cite this

Resistance to gastrointestinal proteases of the short chain peptides having reductive effect in blood pressure. / Seki, Eiji; Osajima, Katsuhiro; Matsufuji, Hiroshi; Matsui, Toshiro; Osajima, Yutaka.

In: Nippon Shokuhin Kagaku Kogaku Kaishi, Vol. 43, No. 5, 01.01.1996, p. 520-525.

Research output: Contribution to journalArticle

Seki, Eiji ; Osajima, Katsuhiro ; Matsufuji, Hiroshi ; Matsui, Toshiro ; Osajima, Yutaka. / Resistance to gastrointestinal proteases of the short chain peptides having reductive effect in blood pressure. In: Nippon Shokuhin Kagaku Kogaku Kaishi. 1996 ; Vol. 43, No. 5. pp. 520-525.
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