Resolution of Hydronephrosis in a Patient With Mucopolysaccharidosis Type II With Enzyme Replacement Therapy

Kei Nishiyama, Takashi Imai, Kazuhiro Okubo, Masafumi Sanefuji, Hidetoshi Takada

Research output: Contribution to journalArticle

Abstract

Mucopolysaccharidosis type II (MPS II) is caused by deficiency of lysosomal enzyme iduronate-2-sulfatase. Insufficient activity of the enzyme results in accumulation of glycosaminoglycans leading to progressive multisystem pathologies. MPS II is less likely to be complicated by kidney and urinary tract problems. We report a boy with MPS II, who developed left hydronephrosis. His hydronephrosis improved after starting enzyme replacement therapy. It was suggested that MPS II was closely associated with the pathogenesis of hydronephrosis.

Original languageEnglish
Pages (from-to)163-165
Number of pages3
JournalUrology
Volume101
DOIs
Publication statusPublished - Mar 1 2017

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Mucopolysaccharidosis II
Enzyme Replacement Therapy
Hydronephrosis
Mucopolysaccharidosis I
Iduronate Sulfatase
Enzymes
Glycosaminoglycans
Urinary Tract
Pathology
Kidney

All Science Journal Classification (ASJC) codes

  • Urology

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Resolution of Hydronephrosis in a Patient With Mucopolysaccharidosis Type II With Enzyme Replacement Therapy. / Nishiyama, Kei; Imai, Takashi; Okubo, Kazuhiro; Sanefuji, Masafumi; Takada, Hidetoshi.

In: Urology, Vol. 101, 01.03.2017, p. 163-165.

Research output: Contribution to journalArticle

Nishiyama, Kei ; Imai, Takashi ; Okubo, Kazuhiro ; Sanefuji, Masafumi ; Takada, Hidetoshi. / Resolution of Hydronephrosis in a Patient With Mucopolysaccharidosis Type II With Enzyme Replacement Therapy. In: Urology. 2017 ; Vol. 101. pp. 163-165.
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