Responses of endothelial cells to hypotonic solutions: lack of regulatory volume decrease

Patrick De Smet, Masahiro Oike, Guy Droogmans, Willy Van Driessche, Bernd Nilius

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Hypotonic stress (HTS) activates a Cl- current and releases intracellular Ca2+ in vascular endothelial cells, but there is no co-activation of K+-channels. The concomitant increase in cell volume, as assessed from the changes in endothelial cell thickness, is not followed by a regulatory volume decrease (RVD). This lack compensation of the volume increase may be explained by the absence of a concomitant activation of a K+ outward current, resulting in an insufficient efflux of osmolytes during HTS.

Original languageEnglish
Pages (from-to)94-96
Number of pages3
JournalPflügers Archiv European Journal of Physiology
Volume428
Issue number1
DOIs
Publication statusPublished - Aug 1 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

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