Responses of the pigmented rabbit retina to NMPTP, a chemical inducer of Parkinsonism

Corinne Wong, Tatsuro Ishibashi, Gail Tucker, Duco Hamasaki

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The electrophysiological and neurochemical effects of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP), a chemical inducer of Parkinsonism in man and monkeys, on the pigmented rabbit retina were determined under both chronic and acute conditions. The implicit time, the oscillatory potentials, and the amplitude of the b-wave of the rabbit electroretinogram were affected; both dopamine and dihydroxyphenylalanine (DOPA) levels were depressed. Ultrastructural analysis of acute and chronic retinas showed the occurrence of an intranuclear filamentous inclusion in the nucleus of some cells in the inner nuclear and ganglion cell layer of chronic samples. The effects of the neurotoxin NMPTP on the retina suggest that dopaminergic metabolism is impaired, which then affects the components of the electroretinogram attributed to both bipolar and amacrine cells. In addition, the retina may provide a model in which to study the bichemical and pharmacological mechanisms of NMPTP toxicity.

Original languageEnglish
Pages (from-to)509-519
Number of pages11
JournalExperimental Eye Research
Volume40
Issue number4
DOIs
Publication statusPublished - Apr 1985
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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