Abstract
The electrophysiological and neurochemical effects of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP), a chemical inducer of Parkinsonism in man and monkeys, on the pigmented rabbit retina were determined under both chronic and acute conditions. The implicit time, the oscillatory potentials, and the amplitude of the b-wave of the rabbit electroretinogram were affected; both dopamine and dihydroxyphenylalanine (DOPA) levels were depressed. Ultrastructural analysis of acute and chronic retinas showed the occurrence of an intranuclear filamentous inclusion in the nucleus of some cells in the inner nuclear and ganglion cell layer of chronic samples. The effects of the neurotoxin NMPTP on the retina suggest that dopaminergic metabolism is impaired, which then affects the components of the electroretinogram attributed to both bipolar and amacrine cells. In addition, the retina may provide a model in which to study the bichemical and pharmacological mechanisms of NMPTP toxicity.
| Original language | English |
|---|---|
| Pages (from-to) | 509-519 |
| Number of pages | 11 |
| Journal | Experimental Eye Research |
| Volume | 40 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jan 1 1985 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
Cite this
Responses of the pigmented rabbit retina to NMPTP, a chemical inducer of Parkinsonism. / Wong, Corinne; Ishibashi, Tatsuro; Tucker, Gail; Hamasaki, Duco.
In: Experimental Eye Research, Vol. 40, No. 4, 01.01.1985, p. 509-519.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Responses of the pigmented rabbit retina to NMPTP, a chemical inducer of Parkinsonism
AU - Wong, Corinne
AU - Ishibashi, Tatsuro
AU - Tucker, Gail
AU - Hamasaki, Duco
PY - 1985/1/1
Y1 - 1985/1/1
N2 - The electrophysiological and neurochemical effects of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP), a chemical inducer of Parkinsonism in man and monkeys, on the pigmented rabbit retina were determined under both chronic and acute conditions. The implicit time, the oscillatory potentials, and the amplitude of the b-wave of the rabbit electroretinogram were affected; both dopamine and dihydroxyphenylalanine (DOPA) levels were depressed. Ultrastructural analysis of acute and chronic retinas showed the occurrence of an intranuclear filamentous inclusion in the nucleus of some cells in the inner nuclear and ganglion cell layer of chronic samples. The effects of the neurotoxin NMPTP on the retina suggest that dopaminergic metabolism is impaired, which then affects the components of the electroretinogram attributed to both bipolar and amacrine cells. In addition, the retina may provide a model in which to study the bichemical and pharmacological mechanisms of NMPTP toxicity.
AB - The electrophysiological and neurochemical effects of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP), a chemical inducer of Parkinsonism in man and monkeys, on the pigmented rabbit retina were determined under both chronic and acute conditions. The implicit time, the oscillatory potentials, and the amplitude of the b-wave of the rabbit electroretinogram were affected; both dopamine and dihydroxyphenylalanine (DOPA) levels were depressed. Ultrastructural analysis of acute and chronic retinas showed the occurrence of an intranuclear filamentous inclusion in the nucleus of some cells in the inner nuclear and ganglion cell layer of chronic samples. The effects of the neurotoxin NMPTP on the retina suggest that dopaminergic metabolism is impaired, which then affects the components of the electroretinogram attributed to both bipolar and amacrine cells. In addition, the retina may provide a model in which to study the bichemical and pharmacological mechanisms of NMPTP toxicity.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022335255&partnerID=8YFLogxK
U2 - 10.1016/0014-4835(85)90073-9
DO - 10.1016/0014-4835(85)90073-9
M3 - Article
C2 - 2988989
AN - SCOPUS:0022335255
VL - 40
SP - 509
EP - 519
JO - Experimental Eye Research
JF - Experimental Eye Research
SN - 0014-4835
IS - 4
ER -