Responses of the pigmented rabbit retina to NMPTP, a chemical inducer of Parkinsonism

Corinne Wong; Tatsuro Ishibashi; Gail Tucker; Duco Hamasaki

doi:10.1016/0014-4835(85)90073-9

Responses of the pigmented rabbit retina to NMPTP, a chemical inducer of Parkinsonism

Corinne Wong, Tatsuro Ishibashi, Gail Tucker, Duco Hamasaki

Research output: Contribution to journal › Article

28 Citations (Scopus)

Abstract

The electrophysiological and neurochemical effects of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP), a chemical inducer of Parkinsonism in man and monkeys, on the pigmented rabbit retina were determined under both chronic and acute conditions. The implicit time, the oscillatory potentials, and the amplitude of the b-wave of the rabbit electroretinogram were affected; both dopamine and dihydroxyphenylalanine (DOPA) levels were depressed. Ultrastructural analysis of acute and chronic retinas showed the occurrence of an intranuclear filamentous inclusion in the nucleus of some cells in the inner nuclear and ganglion cell layer of chronic samples. The effects of the neurotoxin NMPTP on the retina suggest that dopaminergic metabolism is impaired, which then affects the components of the electroretinogram attributed to both bipolar and amacrine cells. In addition, the retina may provide a model in which to study the bichemical and pharmacological mechanisms of NMPTP toxicity.

Original language	English
Pages (from-to)	509-519
Number of pages	11
Journal	Experimental Eye Research
Volume	40
Issue number	4
DOIs	https://doi.org/10.1016/0014-4835(85)90073-9
Publication status	Published - Apr 1985
Externally published	Yes

All Science Journal Classification (ASJC) codes

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

Access to Document

10.1016/0014-4835(85)90073-9

Fingerprint Dive into the research topics of 'Responses of the pigmented rabbit retina to NMPTP, a chemical inducer of Parkinsonism'. Together they form a unique fingerprint.

Cite this

Wong, C., Ishibashi, T., Tucker, G., & Hamasaki, D. (1985). Responses of the pigmented rabbit retina to NMPTP, a chemical inducer of Parkinsonism. Experimental Eye Research, 40(4), 509-519. https://doi.org/10.1016/0014-4835(85)90073-9

@article{422adaa0ca284e4b8e435108f685a25f,

title = "Responses of the pigmented rabbit retina to NMPTP, a chemical inducer of Parkinsonism",

abstract = "The electrophysiological and neurochemical effects of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP), a chemical inducer of Parkinsonism in man and monkeys, on the pigmented rabbit retina were determined under both chronic and acute conditions. The implicit time, the oscillatory potentials, and the amplitude of the b-wave of the rabbit electroretinogram were affected; both dopamine and dihydroxyphenylalanine (DOPA) levels were depressed. Ultrastructural analysis of acute and chronic retinas showed the occurrence of an intranuclear filamentous inclusion in the nucleus of some cells in the inner nuclear and ganglion cell layer of chronic samples. The effects of the neurotoxin NMPTP on the retina suggest that dopaminergic metabolism is impaired, which then affects the components of the electroretinogram attributed to both bipolar and amacrine cells. In addition, the retina may provide a model in which to study the bichemical and pharmacological mechanisms of NMPTP toxicity.",

author = "Corinne Wong and Tatsuro Ishibashi and Gail Tucker and Duco Hamasaki",

year = "1985",

month = apr,

doi = "10.1016/0014-4835(85)90073-9",

language = "English",

volume = "40",

pages = "509--519",

journal = "Experimental Eye Research",

issn = "0014-4835",

publisher = "Academic Press Inc.",

number = "4",

}

TY - JOUR

T1 - Responses of the pigmented rabbit retina to NMPTP, a chemical inducer of Parkinsonism

AU - Wong, Corinne

AU - Ishibashi, Tatsuro

AU - Tucker, Gail

AU - Hamasaki, Duco

PY - 1985/4

Y1 - 1985/4

N2 - The electrophysiological and neurochemical effects of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP), a chemical inducer of Parkinsonism in man and monkeys, on the pigmented rabbit retina were determined under both chronic and acute conditions. The implicit time, the oscillatory potentials, and the amplitude of the b-wave of the rabbit electroretinogram were affected; both dopamine and dihydroxyphenylalanine (DOPA) levels were depressed. Ultrastructural analysis of acute and chronic retinas showed the occurrence of an intranuclear filamentous inclusion in the nucleus of some cells in the inner nuclear and ganglion cell layer of chronic samples. The effects of the neurotoxin NMPTP on the retina suggest that dopaminergic metabolism is impaired, which then affects the components of the electroretinogram attributed to both bipolar and amacrine cells. In addition, the retina may provide a model in which to study the bichemical and pharmacological mechanisms of NMPTP toxicity.

AB - The electrophysiological and neurochemical effects of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP), a chemical inducer of Parkinsonism in man and monkeys, on the pigmented rabbit retina were determined under both chronic and acute conditions. The implicit time, the oscillatory potentials, and the amplitude of the b-wave of the rabbit electroretinogram were affected; both dopamine and dihydroxyphenylalanine (DOPA) levels were depressed. Ultrastructural analysis of acute and chronic retinas showed the occurrence of an intranuclear filamentous inclusion in the nucleus of some cells in the inner nuclear and ganglion cell layer of chronic samples. The effects of the neurotoxin NMPTP on the retina suggest that dopaminergic metabolism is impaired, which then affects the components of the electroretinogram attributed to both bipolar and amacrine cells. In addition, the retina may provide a model in which to study the bichemical and pharmacological mechanisms of NMPTP toxicity.

UR - http://www.scopus.com/inward/record.url?scp=0022335255&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022335255&partnerID=8YFLogxK

U2 - 10.1016/0014-4835(85)90073-9

DO - 10.1016/0014-4835(85)90073-9

M3 - Article

C2 - 2988989

AN - SCOPUS:0022335255

VL - 40

SP - 509

EP - 519

JO - Experimental Eye Research

JF - Experimental Eye Research

SN - 0014-4835

IS - 4

ER -