Responsiveness to interleukin 4 and interleukin 2 of peripheral blood mononuclear cells in atopic dermatitis

Masutaka Furue, Mamitaroh Ohtsuki, Fuyuki Ogata, Yasumasa Ishibashi

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Although the pathogenesis of atopic dermatitis (AD) is unknown, many immunologic abnormalities such as high levels of serum IgE and increase of IgE Fc receptor-positive lymphocytes have been demonstrated. Recently, interleukin 4 (IL-4) has been shown to induce enormously the production of IgE and to enhance the expression of IgE Fc receptor by B cells, suggesting the possible involvement of IL-4 in the pathogenesis of AD. We examined IL-4 responsiveness or interleukin 2 (IL-2) responsiveness of peripheral blood mononuclear cells of 31 patients with AD, 19 healthy individuals, and seven patients with other skin diseases. We found that IL-4 responsiveness of AD was higher than that of non-AD control, although IL-2 responsiveness of AD showed no significant change. However, the value of the IL-4 responsiveness did not significantly correlate with the clinical severity, personal history of respiratory allergy, serum IgE level, or clinical course of patients with AD. The hyperresponsiveness to IL-4 detected in AD was not likely to be due to the effects of steroids or anti-mast cell drugs because the value of IL-4 responsiveness was significantly low, compared to AD, in patients with other skin diseases who were treated similarly. Because the T-cell-enriched population, but not the B-cell-enriched population, showed significant proliferation in response to exogeneous IL-4 or IL-2, T cells were the main population that reacted in our proliferation assay. These results indicate that IL-4-driven proliferative response may be efficiently operative in T cells in patients with AD.

Original languageEnglish
Pages (from-to)468-472
Number of pages5
JournalJournal of Investigative Dermatology
Volume96
Issue number4
DOIs
Publication statusPublished - Jan 1 1991
Externally publishedYes

Fingerprint

Atopic Dermatitis
Interleukin-4
Interleukin-2
Blood Cells
Blood
Immunoglobulin E
T-cells
IgE Receptors
Fc Receptors
Cells
T-Lymphocytes
Skin Diseases
Skin
B-Lymphocytes
Dermatitis
Population
Allergies
Lymphocytes
Serum
Mast Cells

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Responsiveness to interleukin 4 and interleukin 2 of peripheral blood mononuclear cells in atopic dermatitis. / Furue, Masutaka; Ohtsuki, Mamitaroh; Ogata, Fuyuki; Ishibashi, Yasumasa.

In: Journal of Investigative Dermatology, Vol. 96, No. 4, 01.01.1991, p. 468-472.

Research output: Contribution to journalArticle

Furue, Masutaka ; Ohtsuki, Mamitaroh ; Ogata, Fuyuki ; Ishibashi, Yasumasa. / Responsiveness to interleukin 4 and interleukin 2 of peripheral blood mononuclear cells in atopic dermatitis. In: Journal of Investigative Dermatology. 1991 ; Vol. 96, No. 4. pp. 468-472.
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