Restoration of a conduction block after the long-term treatment of CIDP with anti-neurofascin 155 antibodies: Follow-up of a case over 23 years

Haruki Koike, Ryoji Nishi, Shohei Ikeda, Yuichi Kawagashira, Masahiro Iijima, Naoki Atsuta, Tomohiko Nakamura, Masaaki Hirayama, Hidenori Ogata, Ryo Yamasaki, Jun Ichi Kira, Masahisa Katsuno, Gen Sobue

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

We herein report a woman with chronic inflammatory demyelinating polyneuropathy (CIDP) in whom positivity for anti-neurofascin 155 antibodies was revealed 23 years after the onset of neuropathy. The patient initially reported numbness in the face at 50 years of age and subsequently manifested features compatible to typical CIDP. Steroid administration initiated at 54 years of age ameliorated her neuropathic symptoms. Although the nerve conduction indices at 59 years of age deteriorated, those at 68, 72, and 73 years of age showed a gradual recovery. The deterioration and subsequent restoration of compound muscle action potential amplitudes was the most dramatic, suggesting that a conduction block can be reversed earlier than other electrophysiological indices.

Original languageEnglish
Pages (from-to)2061-2066
Number of pages6
JournalInternal Medicine
Volume57
Issue number14
DOIs
Publication statusPublished - 2018

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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