Restraint stress causes tissue-specific changes in the immune cell distribution

Nobuyuki Sudo, Xiao Nian Yu, Hiroshi Sogawa, Chiharu Kubo

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

In this study, the effect of restraint stress on alterations in the immune cell distrubution was examined in bone marrow, liver, thymus, and spleen. In bone marrow, stress induced a striking increase in both the proportion and number of CD3+CD4+, CD3+CD8+, B220(bright)IgM+, CD3-IL2Rβ+ and CD3(int)IL-2Rβ+ cells. Such an increase was partially reversed by pretreatment with RU-486, asteroid receptor antagonist, while it was profoundly enhanced by either sympathectomy with 6-hydroxydopamine hydrobromide or by a β-adrenergic blockade with propranolol, a β-adrenergic receptor antagonist; this suggests that corticosteroids and catecholamines may act in opposition with regard to such an immune-cell accumulation in bone marrow. In the liver, stress decreased the proportions of CD3(int)IL-2Rβ+, CD3-IL2Rβ+, and B220(bright)IgM+ cells, while it increased the proportion of CD3(bright)IL-2Rβ-cells, thus demonstrating that different subpopulations were differentially affected. In the thymus and spleen, stress only slightly affected the proportions of lymphocyte subpopulations, although both tissues showed a drastic reduction in the number of lymphocytes. Taken together, these results suggest that restraint stress induces tissue-specific changes in the immune-cell distribution.

Original languageEnglish
Pages (from-to)113-119
Number of pages7
JournalNeuroImmunoModulation
Volume4
Issue number3
Publication statusPublished - Jan 1998

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Bone Marrow
Thymus Gland
Immunoglobulin M
Spleen
Minor Planets
Mifepristone
Adrenergic Antagonists
Sympathectomy
Oxidopamine
Liver
Lymphocyte Subsets
Lymphocyte Count
Propranolol
Adrenergic Agents
Catecholamines
Adrenal Cortex Hormones

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Neuroscience(all)
  • Immunology

Cite this

Restraint stress causes tissue-specific changes in the immune cell distribution. / Sudo, Nobuyuki; Yu, Xiao Nian; Sogawa, Hiroshi; Kubo, Chiharu.

In: NeuroImmunoModulation, Vol. 4, No. 3, 01.1998, p. 113-119.

Research output: Contribution to journalArticle

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