Restraint stress-induced elevation of endogenous glucocorticoid suppresses migration of granulocytes and macrophages to an inflammatory locus

Koji Mizobe, Kenji Kishihara, Randa Ezz-Din El-Naggar, Gamal A. Madkour, Chiharu Kubo, Kikuo Nomoto

Research output: Contribution to journalArticle

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Abstract

It has been reported that restraint stress gives rise to various immunosuppressive events. In the present study, we focused our interest on an early stage of the host-defense system in which granulocytes, macrophages and natural killer (NK) cells are involved. We observed that an elevation of endogenous glucocorticoid levels in mice induced by 24 h-restraint stress (acute stress) did not significantly reduce the NK activity of the spleen cells but profoundly suppressed the migration of macrophages and granulocytes into peritoneal cavities of the mice at 24 h after an intraperitoneal injection of proteose peptone. The reduced number of the migrated granulocytes and macrophages corresponded to a down-regulated gene expression of such chemotactic factors as MCP-1/JE in the peritoneal exudate cells of the stress-loaded mice. The stress-loaded mice recovered from such a suppressive state upon treatment with the glucocorticoid antagonist, RU-486, or upon adrenalectomy, suggesting that the elevated level of endogenous glucocorticoid is responsible for these suppressive effects of acute stress.

Original languageEnglish
Pages (from-to)81-89
Number of pages9
JournalJournal of Neuroimmunology
Volume73
Issue number1-2
DOIs
Publication statusPublished - Mar 1 1997

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Granulocytes
Glucocorticoids
Macrophages
Mifepristone
Adrenalectomy
Chemotactic Factors
Peritoneal Cavity
Exudates and Transudates
Immunosuppressive Agents
Intraperitoneal Injections
Natural Killer Cells
Spleen
Gene Expression
Therapeutics

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Restraint stress-induced elevation of endogenous glucocorticoid suppresses migration of granulocytes and macrophages to an inflammatory locus. / Mizobe, Koji; Kishihara, Kenji; Ezz-Din El-Naggar, Randa; Madkour, Gamal A.; Kubo, Chiharu; Nomoto, Kikuo.

In: Journal of Neuroimmunology, Vol. 73, No. 1-2, 01.03.1997, p. 81-89.

Research output: Contribution to journalArticle

Mizobe, Koji ; Kishihara, Kenji ; Ezz-Din El-Naggar, Randa ; Madkour, Gamal A. ; Kubo, Chiharu ; Nomoto, Kikuo. / Restraint stress-induced elevation of endogenous glucocorticoid suppresses migration of granulocytes and macrophages to an inflammatory locus. In: Journal of Neuroimmunology. 1997 ; Vol. 73, No. 1-2. pp. 81-89.
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