Results of a long-term follow-up after neuroendoscopic biopsy procedure and third ventriculostomy in patients with intracranial germinomas

Tadahisa Shono, Yoshihiro Natori, Takato Morioka, Rina Torisu, Masahiro Mizoguchi, Shinji Agata, Satoshi Suzuki, Toru Iwaki, Takanori Inamura, Masashi Fukui, Kazunari Oka, Tomio Sasaki

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Abstract

Object. The authors report the results of long-term follow-ups in 12 patients with intracranial germinomas who underwent neuroendoscopic procedures before chemotherapy and radiotherapy, and discuss the usefulness and safety of these procedures. Methods. Between January 1996 and December 2005 at Kyushu University Hospital, 12 patients with intracranial germinomas underwent neuroendoscopic biopsy procedures involving a flexible fiberscope. Eight patients simultaneously underwent endoscopic third ventriculostomy (ETV) for existing obstructive hydrocephalus. All patients received chemotherapy and radiotherapy postoperatively, according to the regimen promulgated by the Japanese Pediatric Brain Tumor Study Group. The patients were followed for an average of 78.6 months (range 15-134 months), and a retrospective study was conducted. Results. Germinomas were histologically verified in all patients. No postoperative deaths or permanent morbidity was related to the neuroendoscopic procedures. No other cerebrospinal fluid diversion, such as that achieved with a ventriculoperitoneal shunt, was needed for the management of hydrocephalus. A complete response to postoperative chemotherapy and radiotherapy was achieved in all cases. Only one patient had a recurrent lesion in the spinal cord 6 years after the initial treatment; however, this patient had undergone only the neuroendoscopic biopsy procedure without ETV. Conclusions. Neuroendoscopic procedures can permit a precise histological diagnosis of intracranial germinomas and are safe and effective in the management of hydrocephalus associated with these tumors. The risk of tumor dissemination due to the neuroendoscopic procedures appears to be minimal when the appropriate chemotherapy and radiotherapy are provided postoperatively.

Original languageEnglish
Pages (from-to)193-198
Number of pages6
JournalJournal of Neurosurgery
Volume107
Issue number3 SUPPL.
DOIs
Publication statusPublished - Sep 1 2007

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Germinoma
Ventriculostomy
Biopsy
Radiotherapy
Hydrocephalus
Drug Therapy
Ventriculoperitoneal Shunt
Brain Neoplasms
Cerebrospinal Fluid
Neoplasms
Spinal Cord
Retrospective Studies
Pediatrics
Morbidity
Safety

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

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Results of a long-term follow-up after neuroendoscopic biopsy procedure and third ventriculostomy in patients with intracranial germinomas. / Shono, Tadahisa; Natori, Yoshihiro; Morioka, Takato; Torisu, Rina; Mizoguchi, Masahiro; Agata, Shinji; Suzuki, Satoshi; Iwaki, Toru; Inamura, Takanori; Fukui, Masashi; Oka, Kazunari; Sasaki, Tomio.

In: Journal of Neurosurgery, Vol. 107, No. 3 SUPPL., 01.09.2007, p. 193-198.

Research output: Contribution to journalArticle

Shono, Tadahisa ; Natori, Yoshihiro ; Morioka, Takato ; Torisu, Rina ; Mizoguchi, Masahiro ; Agata, Shinji ; Suzuki, Satoshi ; Iwaki, Toru ; Inamura, Takanori ; Fukui, Masashi ; Oka, Kazunari ; Sasaki, Tomio. / Results of a long-term follow-up after neuroendoscopic biopsy procedure and third ventriculostomy in patients with intracranial germinomas. In: Journal of Neurosurgery. 2007 ; Vol. 107, No. 3 SUPPL. pp. 193-198.
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AU - Suzuki, Satoshi

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