Results of a nationwide survey of gastrointestinal tumors in Japan

Tetsuhide Ito, Masao Tanaka, Masayuki Imamura

Research output: Contribution to journalArticle

Abstract

We conducted a nationwide survey to estimate the incidence of neuroendocrine gastrointestinal tumors (NETs) newly diagnosed in Japan from 2002 through 2004. Five hundred and fourteen pancreatic endocrine tumors (PETs) and 1,027 gastrointestinal carcinoids (GICs) were recorded and analyzed. Nonfunctioning tumors (NF-PET) constituted 47.7% of PETs. Next in frequency were insulinoma (31.7%) and gastrinoma (8.6%). Malignancy was frequent in NF-PETs (46.1%) and gastrinomas (45.5%), but only 7.4% of insulinomas were malignant. The incidence of multiple endocrine neoplasia type-1 associated with PETs was 7.4%. The incidence of GICs was 28.8%, 5.2%, and 66.0% in the foregut, midgut, and hindgut, respectively. Carcinoid syndrome and metastases were observed in only 1.7% and 5.6% of GICs, respectively. The incidence of NETs in Japan was clarified by this preliminary study. Comparatively large differences in GICs between Japan and Western nations were present with regard to the location, symptomatic status, and prevalence of malignancy. At present, the results of an epidemiologic investigation in 2005 in Japan are being analyzed, and the outcome of the survey in 2005 will be clarified in the very near future.

Original languageEnglish
Pages (from-to)128-132
Number of pages5
JournalNippon Geka Gakkai zasshi
Volume109
Issue number3
Publication statusPublished - May 2008

Fingerprint

Japan
Carcinoid Tumor
Neoplasms
Gastrinoma
Insulinoma
Neuroendocrine Tumors
Incidence
Multiple Endocrine Neoplasia Type 1
Surveys and Questionnaires
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Ito, T., Tanaka, M., & Imamura, M. (2008). Results of a nationwide survey of gastrointestinal tumors in Japan. Nippon Geka Gakkai zasshi, 109(3), 128-132.

Results of a nationwide survey of gastrointestinal tumors in Japan. / Ito, Tetsuhide; Tanaka, Masao; Imamura, Masayuki.

In: Nippon Geka Gakkai zasshi, Vol. 109, No. 3, 05.2008, p. 128-132.

Research output: Contribution to journalArticle

Ito, T, Tanaka, M & Imamura, M 2008, 'Results of a nationwide survey of gastrointestinal tumors in Japan', Nippon Geka Gakkai zasshi, vol. 109, no. 3, pp. 128-132.
Ito, Tetsuhide ; Tanaka, Masao ; Imamura, Masayuki. / Results of a nationwide survey of gastrointestinal tumors in Japan. In: Nippon Geka Gakkai zasshi. 2008 ; Vol. 109, No. 3. pp. 128-132.
@article{33dbd877a397460d879e8febd329ccc6,
title = "Results of a nationwide survey of gastrointestinal tumors in Japan",
abstract = "We conducted a nationwide survey to estimate the incidence of neuroendocrine gastrointestinal tumors (NETs) newly diagnosed in Japan from 2002 through 2004. Five hundred and fourteen pancreatic endocrine tumors (PETs) and 1,027 gastrointestinal carcinoids (GICs) were recorded and analyzed. Nonfunctioning tumors (NF-PET) constituted 47.7{\%} of PETs. Next in frequency were insulinoma (31.7{\%}) and gastrinoma (8.6{\%}). Malignancy was frequent in NF-PETs (46.1{\%}) and gastrinomas (45.5{\%}), but only 7.4{\%} of insulinomas were malignant. The incidence of multiple endocrine neoplasia type-1 associated with PETs was 7.4{\%}. The incidence of GICs was 28.8{\%}, 5.2{\%}, and 66.0{\%} in the foregut, midgut, and hindgut, respectively. Carcinoid syndrome and metastases were observed in only 1.7{\%} and 5.6{\%} of GICs, respectively. The incidence of NETs in Japan was clarified by this preliminary study. Comparatively large differences in GICs between Japan and Western nations were present with regard to the location, symptomatic status, and prevalence of malignancy. At present, the results of an epidemiologic investigation in 2005 in Japan are being analyzed, and the outcome of the survey in 2005 will be clarified in the very near future.",
author = "Tetsuhide Ito and Masao Tanaka and Masayuki Imamura",
year = "2008",
month = "5",
language = "English",
volume = "109",
pages = "128--132",
journal = "Nihon Geka Gakkai zasshi",
issn = "0301-4894",
publisher = "Nihon Geka Gakkai",
number = "3",

}

TY - JOUR

T1 - Results of a nationwide survey of gastrointestinal tumors in Japan

AU - Ito, Tetsuhide

AU - Tanaka, Masao

AU - Imamura, Masayuki

PY - 2008/5

Y1 - 2008/5

N2 - We conducted a nationwide survey to estimate the incidence of neuroendocrine gastrointestinal tumors (NETs) newly diagnosed in Japan from 2002 through 2004. Five hundred and fourteen pancreatic endocrine tumors (PETs) and 1,027 gastrointestinal carcinoids (GICs) were recorded and analyzed. Nonfunctioning tumors (NF-PET) constituted 47.7% of PETs. Next in frequency were insulinoma (31.7%) and gastrinoma (8.6%). Malignancy was frequent in NF-PETs (46.1%) and gastrinomas (45.5%), but only 7.4% of insulinomas were malignant. The incidence of multiple endocrine neoplasia type-1 associated with PETs was 7.4%. The incidence of GICs was 28.8%, 5.2%, and 66.0% in the foregut, midgut, and hindgut, respectively. Carcinoid syndrome and metastases were observed in only 1.7% and 5.6% of GICs, respectively. The incidence of NETs in Japan was clarified by this preliminary study. Comparatively large differences in GICs between Japan and Western nations were present with regard to the location, symptomatic status, and prevalence of malignancy. At present, the results of an epidemiologic investigation in 2005 in Japan are being analyzed, and the outcome of the survey in 2005 will be clarified in the very near future.

AB - We conducted a nationwide survey to estimate the incidence of neuroendocrine gastrointestinal tumors (NETs) newly diagnosed in Japan from 2002 through 2004. Five hundred and fourteen pancreatic endocrine tumors (PETs) and 1,027 gastrointestinal carcinoids (GICs) were recorded and analyzed. Nonfunctioning tumors (NF-PET) constituted 47.7% of PETs. Next in frequency were insulinoma (31.7%) and gastrinoma (8.6%). Malignancy was frequent in NF-PETs (46.1%) and gastrinomas (45.5%), but only 7.4% of insulinomas were malignant. The incidence of multiple endocrine neoplasia type-1 associated with PETs was 7.4%. The incidence of GICs was 28.8%, 5.2%, and 66.0% in the foregut, midgut, and hindgut, respectively. Carcinoid syndrome and metastases were observed in only 1.7% and 5.6% of GICs, respectively. The incidence of NETs in Japan was clarified by this preliminary study. Comparatively large differences in GICs between Japan and Western nations were present with regard to the location, symptomatic status, and prevalence of malignancy. At present, the results of an epidemiologic investigation in 2005 in Japan are being analyzed, and the outcome of the survey in 2005 will be clarified in the very near future.

UR - http://www.scopus.com/inward/record.url?scp=48049090080&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=48049090080&partnerID=8YFLogxK

M3 - Article

C2 - 18536315

AN - SCOPUS:48049090080

VL - 109

SP - 128

EP - 132

JO - Nihon Geka Gakkai zasshi

JF - Nihon Geka Gakkai zasshi

SN - 0301-4894

IS - 3

ER -